PPP2R2D

PPP2R2D
Identifiers
Aliases	PPP2R2D, MDS026, protein phosphatase 2 regulatory subunit Bdelta, B55delta, B55D
External IDs	OMIM: 613992 MGI: 1289252 HomoloGene: 81915 GeneCards: PPP2R2D
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	131,959,834 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	138,883,057 bp[2]
RNA expression pattern
	Top expressed in
	body of pancreas; ; cerebellar hemisphere; ; left adrenal gland; ; ganglionic eminence; ; anterior pituitary; ; prefrontal cortex; ; Achilles tendon; ; Brodmann area 23; ; gastrocnemius muscle; ; left ventricle;
	Top expressed in
	internal carotid artery; ; facial motor nucleus; ; external carotid artery; ; seminiferous tubule; ; primitive streak; ; right ventricle; ; spermatid; ; brown adipose tissue; ; motor neuron; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; protein phosphatase regulator activity;
Cellular component	cytoplasm; protein phosphatase type 2A complex; cytosol;
Biological process	cell division; cell cycle; exit from mitosis; peptidyl-serine dephosphorylation; mitotic cell cycle; developmental process; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	55844
	52432
	ENSG00000175470
	ENSMUSG00000041769
	Q66LE6
	Q925E7
	NM_001003656; NM_001291310; NM_018461
	NM_026391; NM_001347618
	NP_001278239; NP_060931
	NP_001334547; NP_080667
	Wikidata
View/Edit Human	View/Edit Mouse

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene.[5] It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

References

GRCh38: Ensembl release 89: ENSG00000175470 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041769 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Protein phosphatase 2 regulatory subunit Bdelta".

Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M (September 2008). "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling". Development. 135 (17): 2927–37. doi:10.1242/dev.020842. PMC 4940033. PMID 18697906.
Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC (2012). "Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene". PLOS ONE. 7 (4): e35524. Bibcode:2012PLoSO...735524C. doi:10.1371/journal.pone.0035524. PMC 3335092. PMID 22539979.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175470 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041769 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Protein phosphatase 2 regulatory subunit Bdelta".

PPP2R2D

References

Further reading