PRKAR2B

cAMP-dependent protein kinase type II-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR2B gene.[5][6]

PRKAR2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKAR2B, PRKAR2, RII-BETA, protein kinase cAMP-dependent type II regulatory subunit beta
External IDsOMIM: 176912 MGI: 97760 HomoloGene: 37666 GeneCards: PRKAR2B
Orthologs
SpeciesHumanMouse
Entrez

5577

19088

Ensembl

ENSG00000005249
ENSG00000284096

ENSMUSG00000002997

UniProt

P31323

P31324

RefSeq (mRNA)

NM_002736

NM_011158
NM_001364407
NM_001364408

RefSeq (protein)

NP_002727
NP_002727.2

NP_035288
NP_001351336
NP_001351337

Location (UCSC)Chr 7: 107.04 – 107.16 MbChr 12: 32.01 – 32.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.[6]

Interactions

PRKAR2B has been shown to interact with AKAP11 in an advanced Stage.[7]

References

  1. ENSG00000284096 GRCh38: Ensembl release 89: ENSG00000005249, ENSG00000284096 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002997 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Solberg R, Sistonen P, Träskelin AL, Bérubé D, Simard J, Krajci P, Jahnsen T, de la Chapelle A (Sep 1992). "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics. 14 (1): 63–9. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
  6. "Entrez Gene: PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta".
  7. Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (Jul 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis". Developmental Biology. 223 (1): 194–204. doi:10.1006/dbio.2000.9725. PMID 10864471.

Further reading

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