PRMT7

Protein arginine methyltransferase 7 is a protein that in humans is encoded by the PRMT7 gene.[1] Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing.[1][2]

Model organisms

Model organisms have been used in the study of PRMT7 function. A conditional knockout mouse line, called Prmt7tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty five tests were carried out on mutant mice and two significant abnormalities were observed.[5] Fewer than expected homozygous mutant mice survived until weaning and those that did survive displayed evidence of chromosomal instability in a micronucleus test.[5]

References
  1. "Protein arginine methyltransferase 7". Retrieved 2011-12-06.
  2. Miranda, T. B.; Miranda, M.; Frankel, A.; Clarke, S. (2004). "PRMT7 is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity". Journal of Biological Chemistry. 279 (22): 22902–22907. doi:10.1074/jbc.M312904200. PMID 15044439.
  3. "Salmonella infection data for Prmt7". Wellcome Trust Sanger Institute.
  4. "Citrobacter infection data for Prmt7". Wellcome Trust Sanger Institute.
  5. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  6. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. "International Knockout Mouse Consortium".
  8. "Mouse Genome Informatics".
  9. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  10. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  12. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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