PRND

Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene.[5]

PRND
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRND, DOPPEL, DPL, PrPLP, dJ1068H6.4, prion protein 2 (dublet), prion like protein doppel
External IDsOMIM: 604263 MGI: 1346999 HomoloGene: 8236 GeneCards: PRND
Orthologs
SpeciesHumanMouse
Entrez

23627

26434

Ensembl

ENSG00000171864

ENSMUSG00000027338

UniProt

Q9UKY0

Q9QUG3

RefSeq (mRNA)

NM_012409

NM_001126338
NM_001278257
NM_001278520
NM_023043

RefSeq (protein)

NP_036541

NP_001119810
NP_001265186
NP_001265449
NP_075530

Location (UCSC)Chr 20: 4.72 – 4.73 MbChr 2: 131.79 – 131.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000171864 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027338 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: PRND prion protein 2 (dublet)".

Further reading


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