PRSS16

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.[5][6]

PRSS16
Identifiers
AliasesPRSS16, TSSP, protease, serine 16, serine protease 16
External IDsOMIM: 607169 MGI: 1859181 HomoloGene: 38106 GeneCards: PRSS16
Orthologs
SpeciesHumanMouse
Entrez

10279

54373

Ensembl

ENSG00000112812

ENSMUSG00000006179

UniProt

Q9NQE7

Q9QXE5

RefSeq (mRNA)

NM_005865

NM_019429

RefSeq (protein)

NP_005856

NP_062302

Location (UCSC)Chr 6: 27.25 – 27.26 MbChr 13: 22.19 – 22.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000112812 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000006179 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cellular Immunology. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
  6. "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

Further reading


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