Proteinase 3

Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.[5]

PRTN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRTN3, ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, proteinase 3
External IDsOMIM: 177020 MGI: 893580 HomoloGene: 120934 GeneCards: PRTN3
Orthologs
SpeciesHumanMouse
Entrez

5657

19152

Ensembl

ENSG00000277804
ENSG00000196415

ENSMUSG00000057729

UniProt

P24158

Q61096

RefSeq (mRNA)

NM_002777

NM_011178

RefSeq (protein)

NP_002768

NP_035308

Location (UCSC)Chr 19: 0.84 – 0.85 MbChr 10: 79.71 – 79.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.[6]

References

  1. ENSG00000196415 GRCh38: Ensembl release 89: ENSG00000277804, ENSG00000196415 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057729 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Campanelli D, Melchior M, Fu Y, Nakata M, Shuman H, Nathan C, Gabay JE (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine. 172 (6): 1709–15. doi:10.1084/jem.172.6.1709. PMC 2188764. PMID 2258701.
  6. Hilhorst M, van Paassen P, Tervaert JW (October 2015). "Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis". Journal of the American Society of Nephrology. 26 (10): 2314–27. doi:10.1681/ASN.2014090903. PMC 4587702. PMID 25956510.

Further reading

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