PTS Glucitol Family

The PTS Glucitol (Gut) Family (TC# 4.A.4)consists only of glucitol-specific porters, but these occur both in Gram-negative and Gram-positive bacteria. It is part of the PTS-GFL superfamily.

Structure

IIGut of Escherichia coli consists of three proteins, a IIA protein, a putative 4 TMS IIC2 protein and a putative 4 TMS IIC1 protein.[1] The N- and C-termini as well as the IIB domain may thereby be localized to the cell cytoplasm, but the topology has not been established experimentally. IIAGut is believed to be phosphorylated on a histidyl residue, while IIBGut is probably phosphorylated on a cysteyl residue. However, these possibilities have not been demonstrated experimentally.

References
  1. Nguyen, Thai X.; Yen, Ming-Ren; Barabote, Ravi D.; Saier, Milton H. (2006-01-01). "Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system". Journal of Molecular Microbiology and Biotechnology. 11 (6): 345–360. doi:10.1159/000095636. ISSN 1464-1801. PMID 17114898. S2CID 25965070.

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