PANX1

Pannexin 1 is a protein in humans that is encoded by the PANX1 gene.[5]

PANX1
Identifiers
AliasesPANX1, MRS1, PX1, UNQ2529, pannexin 1, OOMD7, Pannexin1
External IDsOMIM: 608420 MGI: 1860055 HomoloGene: 49416 GeneCards: PANX1
Orthologs
SpeciesHumanMouse
Entrez

24145

55991

Ensembl

ENSG00000110218

ENSMUSG00000031934

UniProt

Q96RD7

Q9JIP4

RefSeq (mRNA)

NM_015368

NM_019482

RefSeq (protein)

NP_056183

NP_062355

Location (UCSC)Chr 11: 94.13 – 94.18 MbChr 9: 14.91 – 14.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.[5]

Clinical relevance

Truncating mutations in this gene have been shown to promote breast cancer metastasis to the lungs by allowing cancer cells to survive mechanical stretch in the microcirculation.[6]

Disruptions of this gene have been associated to melanoma tumor progression.[7]

Pannexin 1 is also an important component of membrane channels involved in the formation of thin plasma membrane extensions called apoptopodia and beaded apoptopodia during apoptosis.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000110218 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031934 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Pannexin 1". Retrieved 2012-04-11.
  6. Furlow PW, Zhang S, Soong TD, Halberg N, Goodarzi H, Mangrum C, Wu YG, Elemento O, Tavazoie SF (July 2015). "Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival". Nature Cell Biology. 17 (7): 943–952. doi:10.1038/ncb3194. PMC 5310712. PMID 26098574.
  7. Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW (Aug 2012). "Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype". The Journal of Biological Chemistry. 287 (34): 29184–93. doi:10.1074/jbc.M112.377176. PMC 3436541. PMID 22753409.
  8. Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS (2014). "Unexpected link between an antibiotic, pannexin channels and apoptosis". Nature. 507 (7492): 329–34. Bibcode:2014Natur.507..329P. doi:10.1038/nature13147. PMC 4078991. PMID 24646995.
  9. Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD, Poon IK (2015). "A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure". Nat Commun. 6: 7439. Bibcode:2015NatCo...6.7439A. doi:10.1038/ncomms8439. PMC 4490561. PMID 26074490.

Further reading


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