Parabacteroides

Parabacteroides
Scientific classification
Domain:	Bacteria
Phylum:	Bacteroidota
Class:	Bacteroidia
Order:	Bacteroidales
Family:	"Tannerellaceae"
Genus:	Parabacteroides; Sakamoto and Benno 2006[1]
Type species
	Parabacteroides distasonis[1];
Species
	P. acidifaciens[1]; P. bouchesdurhonensis[1]; P. chartae[1]; P. chinchillae[1]; P. chongii[1]; P. distasonis[1]; P. faecavium[1]; P. faecis[1]; P. goldsteinii[1]; P. gordonii[1]; P. hominis[1]; P. intestinavium[1]; P. intestinigallinarum[1]; P. intestinipullorum[1]; P. johnsonii[1]; P. massiliensis[1]; P. merdae[1]; P. pacaensis[1]; P. pekinense[1]; P. provencensis[1]; P. timonensis[1]

Parabacteroides is a Gram-negative, anaerobic, non-spore-forming genus from the family Tannerellaceae.[2][3][4][5]

P. distasonis, a species of Parabacteroides within the human gut microbiome.

First isolated from fecal specimen in 1933, type strain Parabacteroides distasonis was originally classified under the name Bacteroides distasonis.[6] The strain was re-classified to form the new genus Parabacteroides in 2006.[7] Parabacteroides currently comprise 21 phylogenetically, ecologically, and metabolically diverse species, 11 of which are validly published in the taxonomic database List of Prokaryotic names with Standing in Nomenclature (LPSN).[2]

Within the Parabacteroides genus, species P. distasonis and P. goldsteinii have been associated with beneficial effects in human health, relating to their integral role in gut microbiota along the digestive tract.[8][9][10]

Taxonomy

The taxon ID number used for prokaryotic genus Parabacteroides is 516255.[2] Parent taxon comes from bacterial family Tannerellaceae, identified by number 29533 in the online LPSN database.[2]

Genomics

The genomes of Parabacteroides are highly variable, both across species and within a single strain. For example, genomes isolated from type strain P. distasonis range in size from approximately 4.5 to 5.2 Mb (megabases) and encode over 2,000 functional proteins, signifying substantial variation within the species.[11]

Species

The genus Parabacteroides comprises the following species, 11 of which are validly published by the List of Prokaryotic names with Standing in Nomenclature (LPSN): [2]


Validly Named by the LPSN [2]	Not Validly Named by the LPSN [2]
P. acidifaciens Wang et al. 2019 P. chartae Tan et al. 2012 P. chinchillae Kitahara et al. 2013 P. chongii Kim et al. 2019 P. distasonis (Eggerth and Gagnon 1933) Sakamoto and Benno 2006 P. faecis Sakamoto et al. 2015 P. goldsteinii (Song et al. 2006) Sakamoto and Benno 2006 P. gordonii Sakamoto et al. 2009 P. hominis Liu et al. 2022 P. johnsonii Sakamoto et al. 2007 P. merdae (Johnson et al. 1986) Sakamoto and Benno 2006	P. bouchesdurhonensis Dione et al. 2018 P. faecavium Gilroy et. al 2021 P. intestinavium Gilroy et al. 2021 P. intestinigallinarum Gilroy et al. 2021 P. intestinipullorum Gilroy et al. 2021 P. massiliensis Bellali et al. 2019 P. pacaensis Benabdelkader et al. 2020 P. pekinense Li et al. 2022 P. provencensis Benabdelkader et al. 2020 P. timonensis Bilen et al. 2019

Role in the human gut microenvironment

Part of the bacterial order Bacteroidales present in the human gut, Parabacteroides are commonly found within the gut microenvironment. Parabacteroides species constitute a significant component of microbiota along the digestive tract, benefitting from a commensal relationship with the human body. Intestinal microbiota also benefit the human host, modulating essential metabolism-related processes within the gut microenvironment.[12]

P. distasonis and P. goldsteinii in particular form biofilms in the gut microbiota, allowing these species to survive under harsh conditions and maintain ample populations in extreme pH environments.[8] Recent studies elucidate new applications of Parabacteroides as probiotics, supporting balanced microbiota composition as a benefit to human digestive health.[8] Both P. distasonis and P. goldsteinii exhibit anti-obesity effects via production of secondary bile acids and succinate within the gut microenvironment.[8][10] Studies on Parabacteroides species P. distasonis reveal metabolic benefits of this mechanism, including control of weight gain, decrease in hyperglycemia, and amelioration of hepatic steatosis and other metabolic diseases. [9]

References

Parte, A.C. "Parabacteroides". LPSN.
"Genus: Parabacteroides". lpsn.dsmz.de. Retrieved 2022-11-18.
"UniProt". www.uniprot.org. Retrieved 2022-11-18.
Bergey's manual of systematic bacteriology. David R. Boone, Richard W. Castenholz, George M. Garrity (2nd ed.). New York: Springer. 2011. ISBN 978-0-387-98771-2. OCLC 45951601.{{cite book}}: CS1 maint: others (link)
Schaechter's mechanisms of microbial disease. Moselio Schaechter, N. Cary Engleberg, Victor J. DiRita, Terence Dermody (5th ed.). Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2013. ISBN 978-0-7817-8744-4. OCLC 769141612.{{cite book}}: CS1 maint: others (link)
Eggerth, A. H.; Gagnon, B. H. (1933). "The Bacteroides of Human Feces". Journal of Bacteriology. 25 (4): 389–413. doi:10.1128/jb.25.4.389-413.1933. ISSN 0021-9193. PMC 533498. PMID 16559622.
Sakamoto, Mitsuo; Benno, YoshimiYR 2006 (2006). "Reclassification of Bacteroides distasonis, Bacteroides goldsteinii and Bacteroides merdae as Parabacteroides distasonis gen. nov., comb. nov., Parabacteroides goldsteinii comb. nov. and Parabacteroides merdae comb. nov". International Journal of Systematic and Evolutionary Microbiology. 56 (7): 1599–1605. doi:10.1099/ijs.0.64192-0. ISSN 1466-5034. PMID 16825636.
Wang, Kai; Liao, Mingfang; Zhou, Nan; Bao, Li; Ma, Ke; Zheng, Zhongyong; Wang, Yujing; Liu, Chang; Wang, Wenzhao; Wang, Jun; Liu, Shuang-Jiang; Liu, Hongwei (2019-01-02). "Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids". Cell Reports. 26 (1): 222–235.e5. doi:10.1016/j.celrep.2018.12.028. ISSN 2211-1247. PMID 30605678. S2CID 58618693.
Zeng, Qiang; Li, Dongfang; He, Yuan; Li, Yinhu; Yang, Zhenyu; Zhao, Xiaolan; Liu, Yanhong; Wang, Yu; Sun, Jing; Feng, Xin; Wang, Fei; Chen, Jiaxing; Zheng, Yuejie; Yang, Yonghong; Sun, Xuelin (2019-09-17). "Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities". Scientific Reports. 9 (1): 13424. Bibcode:2019NatSR...913424Z. doi:10.1038/s41598-019-49462-w. ISSN 2045-2322. PMC 6748942. PMID 31530820. S2CID 202580919.
Wu, Tsung-Ru; Lin, Chuan-Sheng; Chang, Chih-Jung; Lin, Tzu-Lung; Martel, Jan; Ko, Yun-Fei; Ojcius, David M.; Lu, Chia-Chen; Young, John D.; Lai, Hsin-Chih (2019-02-01). "Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis". Gut. 68 (2): 248–262. doi:10.1136/gutjnl-2017-315458. ISSN 0017-5749. PMID 30007918. S2CID 51628274.
Yang, Falong; Kumar, Anand; Davenport, Karen Walston; Kelliher, Julia Mae; Ezeji, Jessica C.; Good, Caryn E.; Jacobs, Michael R.; Conger, Mathew; West, Gail; Fiocchi, Claudio; Cominelli, Fabio; Dichosa, Armand Earl Ko; Rodriguez-Palacios, Alexander (2019-09-05). "Complete Genome Sequence of a Parabacteroides distasonis Strain (CavFT hAR46) Isolated from a Gut Wall-Cavitating Microlesion in a Patient with Severe Crohn's Disease". Microbiology Resource Announcements. 8 (36): e00585–19. doi:10.1128/MRA.00585-19. ISSN 2576-098X. PMC 6728636. PMID 31488526.
Rolls, Edmund T. (2016). "Reward Systems in the Brain and Nutrition". Annual Review of Nutrition. 36 (1): 435–470. doi:10.1146/annurev-nutr-071715-050725. PMID 27146018.