Patatin

Patatin is a family of glycoproteins found in potatoes (Solanum tuberosum) and is also known as tuberin as it is commonly found within vacuoles of parenchyma tissue in the tuber of the plant. They consist of about 366 amino acids all making up and isoelectric point of 4.9. They have a molecular weight ranging from 40 to 45 kDa, but are commonly found as a 80kDa dimer.[1] The main function of patatin is as a storage protein but it also has lipase activity and can cleave fatty acids from membrane lipids.[2][3] The patatin protein makes up about 40% of the soluble protein in potato tubers.[4] Members of this protein family have also been found in animals.

Potato tubers

Allergy

Patatin is identified as a major cause of potato allergy.[5] It has found to be similar to latex, and when in contact with open skin, there has been an increase of immunoglobulin E which causes some allergic reactions and symptoms, such as asthmatic symptoms, or atopic dermatitis.[6] It is unclear as to why the plant does this, however it could be a potential defense mechanism against insects.[7]

References
  1. Racusen, David; Weller, David L. (1984). "Molecular Weight of Patatin, a Major Potato Tuber Protein1". Journal of Food Biochemistry. 8 (2): 103–107. doi:10.1111/j.1745-4514.1984.tb00318.x. ISSN 1745-4514.
  2. Shewry PR (2003). "Tuber storage proteins". Ann. Bot. 91 (7): 755–69. doi:10.1093/aob/mcg084. PMC 4242388. PMID 12730067.
  3. Bánfalvi Z, Kostyál Z, Barta E (1994). "Solanum brevidens possesses a non-sucrose-inducible patatin gene". Mol. Gen. Genet. 245 (4): 517–22. doi:10.1007/BF00302265. PMID 7808402. S2CID 6862380.
  4. Mignery GA, Pikaard CS, Park WD (1988). "Molecular characterization of the patatin multigene family of potato". Gene. 62 (1): 27–44. doi:10.1016/0378-1119(88)90577-X. PMID 3371664.
  5. http://cme.medscape.com/viewarticle/420552 Food Allergy: New Insights and Management Strategies (03/05/2000), paragraph: Potato Allergy
  6. Seppälä, U.; Alenius, H.; Turjanmaa, K.; Reunala, T.; Palosuo, T.; Kalkkinen, N. (January 1999). "Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato". The Journal of Allergy and Clinical Immunology. 103 (1 Pt 1): 165–171. doi:10.1016/s0091-6749(99)70541-5. ISSN 0091-6749. PMID 9893201.
  7. "Patatin - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-04-26.


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