Phillyrin
Phillyrin is an endophytic fungal isolate with anti-obesity activity. It can be produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa. It can also be prepared directly from Forsythia suspensa.[1]
Names | |
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IUPAC name
(7α,7′β,8α,8′α)-3,3′,4′-Trimethoxy-7,9′:7′,9-diepoxylignan-4-yl β-D-glucopyranoside | |
Systematic IUPAC name
(2S,3R,4S,5S,6R)-2-{4-[(1R,3aR,4S,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenoxy}-6-(hydroxymethyl)oxane-3,4,5-triol | |
Other names
Forsythin | |
Identifiers | |
3D model (JSmol) |
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Properties | |
C27H34O11 | |
Molar mass | 534.55 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references |
Notes
- Su, Hai-xia; Yao, Sheng; Zhao, Wen-Feng; Li, Min-jun; Liu, Jia; Shang, Wei-Juan; Xie, Hang; Ke, Chang-Qiang; Hu, Hang-Chen; Gao, Mei-na; Yu, Kun-Qian; Liu, Hong; Shen, Jing-Shan; Tang, Wei; Zhang, Lei-ke; Xiao, Geng-fu; Ni, Li; Wang, Dao-wen; Zuo, Jian-Ping; Jiang, Hua-Liang; Bai, Fang; Wu, Yan; Ye, Yang; Xu, Ye-Chun (2020). "Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients". Acta Pharmacologica Sinica. 41 (9): 1167–1177. doi:10.1038/s41401-020-0483-6. PMC 7393338. PMID 32737471.
- Zhang Q, Wei X, Wang J (December 2012). "Phillyrin produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa". Fitoterapia. 83 (8): 1500–5. doi:10.1016/j.fitote.2012.08.017. PMID 22960349.
- Zhao Y, Li F, Yang J, An X, Zhou M (February 2005). "[Effect of phillyrin on the anti-obesity in nutritive obesity mice]". Zhong Yao Cai (in Chinese). 28 (2): 123–4. PMID 15981888.
- Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatography
HB Li, F Chen - Journal of Chromatography A, 2005.
- Ultrasound-assisted extraction of phillyrin from Forsythia suspensa. EQ Xia, XX Ai, SY Zang, TT Guan, XR Xu, HB Li - Ultrasonics Sonochemistry, 2011
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