Phloretin hydrolase

In enzymology, a phloretin hydrolase (EC 3.7.1.4) is an enzyme that catalyzes the chemical reaction

phloretin + H2O phloretate + phloroglucinol
phloretin hydrolase
Identifiers
EC no.3.7.1.4
CAS no.37289-38-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are phloretin and H2O, whereas its two products are phloretate and phloroglucinol.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon–carbon bonds in ketonic substances. The systematic name of this enzyme class is 2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase. This enzyme is also called lactase-phlorizin hydrolase.

References

    • Minamikawa T, Jayasankar NP, Bohm BA, Taylor IE, Towers GH (1970). "An inducible hydrolase from Aspergillus niger, acting on carbon-carbon bonds, for phlorrhizin and other C-acylated phenols". Biochem. J. 116 (5): 889–97. PMC 1185512. PMID 5441377.


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