Phloroglucinol reductase

In enzymology, a phloroglucinol reductase (EC 1.3.1.57) is an enzyme that catalyzes the chemical reaction

dihydrophloroglucinol + NADP+ phloroglucinol + NADPH + H+
phloroglucinol reductase
Identifiers
EC no.1.3.1.57
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are dihydrophloroglucinol and NADP+, whereas its 3 products are phloroglucinol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dihydrophloroglucinol:NADP+ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.

References

    • Haddock JD, Ferry JG (1989). "Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41". J. Biol. Chem. 264 (8): 4423–7. PMID 2925649.


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