Phosphoethanolamine N-methyltransferase

In enzymology, a phosphoethanolamine N-methyltransferase (EC 2.1.1.103) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + ethanolamine phosphate S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
phosphoethanolamine N-methyltransferase
Identifiers
EC no.2.1.1.103
CAS no.171040-79-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and ethanolamine phosphate, whereas its two products are S-adenosylhomocysteine and N-methylethanolamine phosphate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase. This enzyme is also called phosphoethanolamine methyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

    • Datko AH, Mudd SH (December 1988). "Enzymes of phosphatidylcholine synthesis in lemna, soybean, and carrot". Plant Physiology. 88 (4): 1338–48. doi:10.1104/pp.88.4.1338. PMC 1055762. PMID 16666464.


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