Phosphogluconate dehydratase
The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction
- 6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O
| phosphogluconate dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 6-Phosphogluconate dehydratase monomer, Shewanella oneidensis | |||||||||
| Identifiers | |||||||||
| EC no. | 4.2.1.12 | ||||||||
| CAS no. | 9024-33-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-Dgluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.
References
- MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239: 3505–10. PMID 14245409.
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