Phthalide

Phthalide
Names
	Preferred IUPAC name 2-Benzofuran-1(3H)-one
	Other names Phthalolactone
Identifiers
CAS Number	87-41-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:38085;
ChemSpider	6621;
ECHA InfoCard	100.001.586
PubChem CID	6885;
UNII	8VV922U86J;
CompTox Dashboard (EPA)	DTXSID0052594 ;
	InChI InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYSA-N; InChI=1/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2 Key: WNZQDUSMALZDQF-UHFFFAOYAW;
	SMILES O=C1OCc2ccccc12;
Properties
Chemical formula	C8H6O2
Molar mass	134.134 g·mol−1
Melting point	75 to 77 °C (167 to 171 °F; 348 to 350 K)[1]
Boiling point	290 °C (554 °F; 563 K)[2]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Phthalide is an organic chemical compound with the molecular formula C₈H₆O₂. It is a white solid and the simplest benzo lactone. It is prepared from hydroxymethylbenzoic acid.[3]

Phthalides

The phthalide core is found a variety of more complex chemical compounds including dyes (such as phenolphthalein), fungicides (such as tetrachlorophthalide, often referred to simply as "phthalide"), and natural oils (such as butylphthalide).

Examples

Phenolphthalein
Tetrachlorophthalide
Butylphthalide

References

Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.
Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.
J. H. Gardner, C. A. Naylor, Jr (1936). "Phthalide". Organic Syntheses. 16: 71. doi:10.15227/orgsyn.016.0071.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[1] Kumar, R. Arun; Maheswari, C. Uma; Ghantasala, Satheesh; Jyothi, C.; Reddy, K. Rajender (2011). "Synthesis of 3H-Quinazolin-4-ones and 4H-3,1-Benzoxazin-4-ones via Benzylic Oxidation and Oxidative Dehydrogenation using Potassium Iodide-tert-Butyl Hydroperoxide". Advanced Synthesis & Catalysis. 353 (2+3): 401–410. doi:10.1002/adsc.201000580.

[2] Kus, Nermin Simsek (2008). "Some oxidation reactions with molecular oxygen in subcritical water". Asian Journal of Chemistry. 20 (2): 1226–1230.

[3] J. H. Gardner, C. A. Naylor, Jr (1936). "Phthalide". Organic Syntheses. 16: 71. doi:10.15227/orgsyn.016.0071.{{cite journal}}: CS1 maint: multiple names: authors list (link)