Pindone

Pindone is an anticoagulant drug[3] for agricultural use. It is commonly used as a rodenticide in the management of rat and rabbit populations.

Pindone
Names
Preferred IUPAC name
2-(2,2-Dimethylpropanoyl)-1H-indene-1,3(2H)-dione
Other names
2-Pivaloyl-1,3-indandione
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.001.330
KEGG
UNII
  • InChI=1S/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3 checkY
    Key: RZKYEQDPDZUERB-UHFFFAOYSA-N checkY
  • InChI=1/C14H14O3/c1-14(2,3)13(17)10-11(15)8-6-4-5-7-9(8)12(10)16/h4-7,10H,1-3H3
    Key: RZKYEQDPDZUERB-UHFFFAOYAX
  • O=C2c1ccccc1C(=O)C2C(=O)C(C)(C)C
Properties
C14H14O3
Molar mass 230.26 g/mol
Appearance Bright-yellow powder[1]
Odor almost none
Density 1.06 g/mL
Melting point 110 °C (230 °F; 383 K)
0.002% (25°C)[1]
Hazards
Lethal dose or concentration (LD, LC):
280 mg/kg (rat, oral)
75 mg/kg (dog, oral)
150 mg/kg (rabbit, oral)[2]
NIOSH (US health exposure limits):
PEL (Permissible)
 TWA 0.1 mg/m3[1]
REL (Recommended)
 TWA 0.1 mg/m3[1]
IDLH (Immediate danger)
 100 mg/m3[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

It is pharmacologically analogous to warfarin and inhibits the synthesis of Vitamin K-dependent clotting factors.

See also

References
  1. NIOSH Pocket Guide to Chemical Hazards. "#0516". National Institute for Occupational Safety and Health (NIOSH).
  2. "Pindone". Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health (NIOSH).
  3. Robinson MH, Twigg LE, Wheeler SH, Martin GR (March 2005). "Effect of the anticoagulant, pindone, on the breeding performance and survival of merino sheep, Ovis aries". Comp. Biochem. Physiol. B. 140 (3): 465–73. doi:10.1016/j.cbpc.2004.11.011. PMID 15694595.


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