Pleuran

Pleuran is an insoluble polysaccharide (β-(1,3/1,6)-D-glucan), isolated from Pleurotus ostreatus.[1]

Pleuran
Identifiers
ChemSpider
  • none
Properties
(C6H10O5)x
Molar mass Variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pleuran belongs to a group of glucose polymers commonly called beta-glucans demonstrating biological response modifier properties. These immunomodulating properties render the host more resistant to infections and neoplasms.[2]

In a study published in December 2010, pleuran demonstrated to have a protective effect against exercise-induced suppression of immune cell activity (NK cells) in subjects taking 100 mg per day.[3]

In another study published in 2011, pleuran reduced the incidence of upper respiratory tract infections and increased the number of circulating NK cells.[4]

Pleuran is also being studied as a potential immunologic adjuvant.[5]

References
  1. Karácsonyi S, Kuniak L (1994). "Polysaccharides of Pleurotus ostreatus: Isolation and structure of pleuran, an alkali-insoluble β-glucan". Carbohydrate Polymers. Elsevier. 24 (2): 107–111. doi:10.1016/0144-8617(94)90019-1.
  2. Di Luzio, NR (1985). "Update on the immunomodulating activities of glucans". Springer Seminars in Immunopathology. Germany: Springer Verlag. 8 (4): 387–400. doi:10.1007/BF01857392. PMID 4089757. S2CID 24803241.
  3. Bobovčák, M; Kuniaková, R, Gabriž, J, Majtán, J (December 2010). "Effect of Pleuran (β-glucan from Pleurotus ostreatus) supplementation on cellular immune response after intensive exercise in elite athletes". Applied Physiology, Nutrition, and Metabolism. 35 (6): 755–62. doi:10.1139/h10-070. PMID 21164546.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Bergendiova, K; Tibenska, E, Majtan, J (2011-01-20). "Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes". European Journal of Applied Physiology. 111 (9): 2033–40. doi:10.1007/s00421-011-1837-z. PMID 21249381. S2CID 25411018.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Vogel FR, Powell MF, Alving CR (1998). "A Compendium of Vaccine Adjuvants and Excipients" (PDF). Pharmaceutical Biotechnology. 2nd ed. National Institute of Allergy and Infectious Diseases. 6: 141–228. doi:10.1007/978-1-4615-1823-5_7. ISBN 978-1-4613-5737-7. PMID 7551218. Retrieved 2008-05-08.


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