Poly(a) binding protein interacting protein 2b
Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene. [5]
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| Aliases | PAIP2B, poly(A) binding protein interacting protein 2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611018 MGI: 2386865 HomoloGene: 25798 GeneCards: PAIP2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].
References
- GRCh38: Ensembl release 89: ENSG00000124374 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000045896 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Poly(A) binding protein interacting protein 2B". Retrieved 2018-05-10.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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