Potassium channel RNA editing signal

Potassium channel RNA editing signal
Potassium channel RNA editing signal
	Predicted secondary structure and sequence conservation of K_chan_RES
Identifiers
Symbol	K_chan_RES
Rfam	RF00485
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
SO	SO:0000233
PDB structures	PDBe

The potassium channel RNA editing signal is an RNA element found in human Kv1.1 and its homologues which directs the efficient modification of an adenosine to inosine by an adenosine deaminase acting on RNA (ADAR). The ADAR modification causes an isoleucine/valine recoding event which lies in the ion-conducting pore of the potassium channel. It is thought that this editing event targets the process of fast inactivation and allows a more rapid recovery from inactivation at negative potentials.[1]

References

Bhalla T, Rosenthal JJ, Holmgren M, Reenan R (October 2004). "Control of human potassium channel inactivation by editing of a small mRNA hairpin". Nature Structural & Molecular Biology. 11 (10): 950–956. doi:10.1038/nsmb825. PMID 15361858. S2CID 34081059.

External links

Page for Potassium channel RNA editing signal at Rfam

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[1] Bhalla T, Rosenthal JJ, Holmgren M, Reenan R (October 2004). "Control of human potassium channel inactivation by editing of a small mRNA hairpin". Nature Structural & Molecular Biology. 11 (10): 950–956. doi:10.1038/nsmb825. PMID 15361858. S2CID 34081059.