Maddam Sir

• Gulki Joshi as SHO Haseena Malik, a.k.a. Maddam Sir (2020–2023): Shahjahan and Noorjahan's daughter; Anubhav's ex-fiancée; Karishma's mentor and close friend, and Naina's friend and batchmate. At the end of series, she is promoted to DSP and indicates that she survived the fatal blast at MPT.[5][6]
• Yukti Kapoor as
  • SI Karishma Singh (2020–2023): Kaushalya's twin sister; Anubhav's cousin; Pushpa and Pyare's daughter-in-law, and Haseena's protective, close friend.[7]
  • Kaushalya Singh, alias Kareena (2022): An actress, Karishma's twin sister, and Anubhav's cousin.[8]
• Bhavika Sharma as Cybercrime Specialist Constable Santosh "Santu" Sharma (2020–2023): Cheetah's love interest, who is suspended due to his negligence.[9][10]
• Sonali Pandit Naik as head constable Pushpa Singh (2020–2023): MPT's oldest member, Pyare's widow, and Karishma's mother-in-law.[11]
• Yashkant Sharma as Constable Cheeteshwar "Cheetah" Chaturvedi (2020–2023): A women's psychologist at MPT and Santu's love interest, later replaced by Priyanshu Singh.
• Ajay Jadhav as
  • Billeshwar "Billu" Champat (2020–2023): A thief turned spy, who enjoys living in jail because he has no other place to live.
  • Commissioner Vikram Ghosh (2023): Billu's lookalike, Lucknow's new commissioner, and Shobhna's husband.

• Satyapal Landge as Badnaam (2020–2023): Tea vendor near the MPT.
• Ashwani Rathore as Iqbal (2020–2023): The local barber.
• Darpan Shrivastava as Usman (2020): A local biriyani vendor; replaced by Harveer Singh.
• Gaurav Wadhwa as Sunny Chaddha (2020, 2022): A reporter who has a crush on Santosh;
  • Jatin Arora replaced Wadhwa as Sunny Chaddha. (2020–2021)
• Rajesh Dubey as DSP Mahesh Singh (2020–2023): Anubhav's predecessor as DSP.
• Umesh Bajpai as Fassruddin Nawab Sahab (2020–2023): Owner of the MPT building and Raees and Zeenat's father, who has a crush on Head Constable Pushpa Singh.
• Nimesh Soni as
  • Bulbul Pandey (2020–2023): SHO of Jankipooram Police Thana, Pallavi's husband, and Champak's senior and brother-in-law, who is temporarily transferred to MPT.
  • Kartik Bajaj (2020): Misogynistic owner of a cab company.
  • Balli (2020): Dishonest owner of the LPJ diet-plan company.
• Amit Kumar Sinha as Champak Chaudhary (2020–2023): A Jankipooram Police Thaana constable, Pallavi's brother, and Bulbul's junior and brother-in-law.
• Disha Savla as Pallavi Pandey (2020, 2022–2023): Champak's sister and Bulbul's wife.
• Rahil Azam as DSP Anubhav Singh(2020–2022): An IB negotiation specialist and Lucknow DSP, Karishma and Kaushalya 's cousin, and Haseena's ex-fiancé. When he turns evil, Karishma and Haseena kill him.[12]
• Esha Kansara as SI/SHO Misri Pandey (2020, 2022–2023): A corrupt police officer who temporarily comes to MPT.[13]
• Roopa Divetia as Noorjahan Malik (2021): Haseena's mother;[14] replaced 2021–2023 by Utkarsha Naik.
• Salman Shaikh as Rajvir Tomar, a.k.a. Computer (2021): Head constable of Jankipooram Police Thaana who has a crush on Karishma Singh, not knowing that she is married.
• Jignesh Modi as Chedi (2021): Jankipooram Police Thaana constable.
• Pankhuri Awasthy Rode as ASI Mira (2021–2023): A humanoid robot police officer invented by C.A.R.D. Research Institute, who was sent to MPT for a 90-day trial to learn emotions under Karishma Singh. She shoots Haseena, and returns to the MPT as Mira G.[15]
• Prakash Ramchandani as Secret Agent Ajay Bakshi (2021–2023): Anubhav's senior, who saves Haseena's life and asks her to pose as Mumbai vada pav vendor Urmila Mahadev Mhatre to catch the people who tried to murder her for the hard disk.
• Savi Thakur as SHO Amar Vidrohi (2022): Yogita's younger brother and Bunty's adoptive father who is temporarily in charge of the MPT.[16]
• Jay Pathak as Harendra Singh, a.k.a. Deewan Ji (2022): MPT head constable under Amar Vidrohi.
• Rachana Parulkar as Advocate Shivani Pawar, a.k.a. Shivani Tai (2022–2023): Chingaari Gang leader turned Allahabad High Court advocate.[17]
• Prachi Bohra as Binny Chaudhary (2022): Chingaari Gang member.[17]
• Sulabha Arya as Saira Begum (2022): Founder of the Chingaari Gang, who is accidentally shot dead by Shivani.[17]

• Divyangana Jain as:
  • Rani (2020–2021), a career criminal.
  • Cherry (2023), a criminal mastermind who is arrested by Haseena and Karishma.
• Shilpa Shinde as ACP Naina Mathur (2023), Haseena's batchmate and friend.[18][19]
• Vaishali Thakkar as Head Constable Babita Sarkar (2020), a temporary replacement for Pushpa who had trained Haseena and Karishma.
• Roopam Sharma as Mona (2021), a corrupt clinical psychologist.
• Lakshya Handa as Avtaar Kapoor (2021), Karishma's boss.
• Kavita Kaushik as IPS Chandramukhi Chautala from F.I.R. (2022).[20]
• Shubhangi Gokhale as Cheeteshwar's aunt (2022).
• Simmi Ghoshal as Binno, a victim of noise pollution (2021).
• Guru Saran Tiwari as Yash Kapoor, director of Kareena's film, who is involved with terrorist group which tried to use Kareena as a suicide bomber (2022).
• Tanya Abrol as Dipti, a female wrestler who is the victim of discrimination.
• Trishna Vivek as
  • Dr. Archana Nagar, who performed illegal gender tests (2020).
  • Sudha Narayan, an NCG officer who suspected that Haseena was a drug smuggler (2020).
• Mahi Sharma as
  • Mahi, the fake Karishma Singh (2020).
  • Nisha Amrit, Roshni's mother, a social-media blogger accused of involvement in a terrorist association (2021).
• Neha Tiwari as Chandu, the fake Santosh Sharma (2020).
• Shefali Rana as the fake Pushpa Singh (2020).
• Ananya Dwivedi as Zoya, a child with kidney disease whose doctor donates a kidney to her (2020).
• Rishikesh Ingley as
  • Dr. Vikas, Zoya's doctor.
  • Rahul, a dishonest cashier (2021).
• Pallavi Pradhan as Savitri Singh, Ajay's mother (2020).
• Govind Khatri as Mahipal Singh (2021): Genda's husband, Mansi's father, Haseena's adoptive uncle, and owner of Prasuti Charitable Hospital.
• Hunar Hali Gandhi as Genda Rani (2021): Mahipal's wife and Mansi's adoptive mother, mastermind of the conspiracy to inject a virus into pregnant women at Prasuti Charitable Hospital.
• Swasti Katyal as Mansi Singh, Mahipal's daughter and Genda's adopted daughter (2021).
• Tarka Pednekar as
  • Gauri, Asthana's sister (2020).
  • Manu, Rani's right hand and advisor (2021).
  • Dolly, a divorcee who is harassed by her boss (2021).
• Anupama Prakash as Ileana, Billu's girlfriend (2020).
• Manoj Chandila as
  • Ajay Kumar, an actor who insults Pushpa Singh and the police (2020).
  • Manav, Keshav's boss (2020).
  • Kareena's co-star in her film (2022).
• Pranay Dixit as
  • An actor who is invited to Santosh Sharma's fake wedding (2020).
  • Mr. Joseph, head chef of the Yo Kabab company (2020).
  • Victor, Nancy's husband who is involved with the dangerous criminal Musa (2020).
  • Shankar, Haldi's first husband who blackmails her (2020).
  • Shekhar, who wants his wife Pallavi to focus on herself instead of her family (2021).
  • Rohit, Chandrika's husband (2021).
  • Abhinav Jasuja, a gym owner falsely accused of domestic violence by his wife (2021).
  • Mukesh aka Qaidi Zameer, a detective-novel writer (2021).
  • Subod, Jharna's husband (2021).
  • Rohit, Mayui's husband who cheats on her (2022).
  • Arun, a man who pretends to be blind (2022).
  • Narayan, Dhanalakshmi's husband, who hides his phone from his wife to conceal his financial problems (2022).
  • Barkha's husband, who tortured his wife (2023).
• Preeti Shukhla[21] as
  • Sona, Montu's wife (2020).
  • Simran, Rahul's wife, who brought a bomb to MPT (2020).
  • Chandrika, Rohit's wife, who hires a detective to investigate her husband (2021).
  • Rupa Jasuja, Abhinav's wife, who falsely accuses her husband of domestic violence (2021).
  • Jharna, Subod's wife (2021).
  • Manju, a nurse pressured by her career and family (2022).
  • Trisha, who has hallucinations (2022).
  • Meethi Shukla, who seizes her landlord's house with her mother-in-law (2022).
• Kunnal Sheth as
  • Monty Sharma, Sona's husband, who created App Zara to replace wives (2020).
  • Radhe, Haseena's helper who was denied paternity leave (2020).
  • Gopal, fake husbands of Nawab Sahab's unmarried tenants (2020).
  • Keshav, pressured by his boss to work at the expense of his wife (2021).
  • Kailash, cheated by an online friend (2021).
  • Jaidev, an actor in pan masala advertisements (2021).
  • Manu, Tanu's husband who is five years younger (2022).
  • Rohan Acharya, owner of the Ummidhai website where poor people receive medical help (2022).
  • Kamal Sharma, an amnesiac abandoned by his brother (2022).
• Urvi Gor as
  • Alia, mistreated by her brother-in-law (2021).
  • Trisha Gulati, kidnapped on New Year's Eve (2021).
  • Chorni, a thief with a sham marriage to Cheetah Chaturvedi (2022).
• Soneer Vadhera as
  • Rahul Mallya, Simran's husband who threatened to explode a bomb to gain his in-laws' respect (2020).
  • Shekhar, Shikha's husband, whose newborn child was stolen (2020).
  • Ashok, an alcoholic who annoyed his wife (2021).
  • Rajesh, Indu's husband (2022).
• Urmila Tiwari as
  • Anita Chauhan, Vijay's wife (2020).
  • Shalini, a beauty-parlour owner who is cheated in a dating app (2021).
  • Pratha, a girl forced to follow superstitious rituals by her mother (2021).
  • Priyali Singh, the fake Aparna Bansal (2021).
  • Nafeesa Ansari, a female don who conducted fake crowdfunding campaigns (2022).
  • Asha, Badnam's sister (2022).
• Shrashti Maheshwari as Riya, the commissioner's daughter who came to MPT to write about the station (2022).
• Piya Valecha as Mrs. Malkhani, owner of the Batterfly club (2021).
• Amit Mistry as Vijay Chauhan, Anita's husband (2020).
• Dolly Chawla as
  • Haldi, Brijesh's wife, who was mistreated by her ex-husband's parents (2020).
  • Indu, Rajesh's wife (2022).
• Apara Jariwala as Sarita Singh, Pushpa's aunt-in-law; Karishma's grand-aunt-in-law (2022).
• Tejal Adivarekar as Malaika, Pushpa and Karishma's home help (2021–2022).
• Ashish Pawar as Sajan, Urmila's (Haseena's) supporter, friend and admirer (2022).
• Prem Vallabh as Mr. Chaturvedi, Cheeta's father (2022).
• Anju Rajiv as Mrs. Chaturvedi, Cheeta's mother (2022).
• Anupama Solanki as Dipti, a creative director with an advertising agency (2022).[22]
• Abhay Bhadoriya as Bunty, a blackmailing teenager addicted to pizza (2022).
• Aman Mishra as Adil Shaikh, an arms dealer chosen by Haseena for her marriage (2022).
• Akansha Sharma as Rama, Karishma's best friend in childhood (2022).
• Rakhi Sawant as Begum, a thief along with her lover, Badshah.[23]
• Ketan Singh as Badshah, a thief along with his lover, Begum.
• Tunisha Sharma as ASP Aditi Jammwal from Hero - Gayab Mode On (2021).
• Deepak Pareek as Honourable Secretary Advocate Dakshesh Joshipura from Wagle Ki Duniya - Nayi Peedhi Naye Kissey.
• Sayantani Ghosh as Daljeet Bagga from Tera Yaar Hoon Main.
• Vijay Kashyap as Col. Pushpinder Batra, director of Parakram SAF from Ziddi Dil Maane Na.
• Gulfam Khan as Mrs. Batra from Ziddi Dil Maane Na.
• Karan Veer Mehra as Abhay, Koel's husband from Ziddi Dil Maane Na.
• Prathmesh Sharma as Bala, Parakram SAF cadet from Ziddi Dil Maane Na.
• Shaleen Malhotra as Special Agent Karan Shergill from Ziddi Dil Maane Na.
• Kaveri Priyam as Cadet Dr. Monami Mahajan from Ziddi Dil Maane Na.
• Kunal Karan Kapoor as Cadet Siddharth Ganju from Ziddi Dil Maane Na.
• Diljot Kaur Chhabra as Special Agent Sanjana Dubey from Ziddi Dil Maane Na.
• Aditya Deshmukh as Special Agent Faizuddin Siddiqui from Ziddi Dil Maane Na.
• Simple Kaul as Cadet Koel Roy from Ziddi Dil Maane Na.
• Ankit Bathla as Kabir (2020).

Before its premiere, the series was entitled Mahila Police Thana. In early February 2020, the main cast promoted it in Lucknow.[24]

Bhavika Sharma left the series in 2022 because she was unhappy with the development of her character.[25]