Proboscipedia (fly gene)

Proboscipedia (pb) is a protein coding gene in Drosophila melanogaster.

Homeotic protein Proboscipedia
Identifiers
OrganismDrosophila melanogaster
Symbolpb
UniProtP31264
Search for
StructuresSwiss-model
DomainsInterPro

Function

This hox gene participates in the development of the labial and maxillary palps and mouthparts in the Drosophila fly. The pb gene is known to regulate the location of the antenna, maxillary palp, tarsus and proboscis identities.[1]

Taxonomy

Proboscipedia belongs to the Antennapedia (Antp) homeobox family and the Proboscipedia subfamily.[2] A homeobox gene is a transcription factor in which a region known as a homeodomain binds to a target gene promoter and controls the differentiation and development of cells. The pb gene is evidenced to be associated with the Sex combs reduced (Scr) gene. Both of these are essential for determination of the proboscis, a long flexible mouthpart in many insects used for the purpose of sucking.[1]

Mutations

Mutated versions of the pb gene result in prothoracic (anterior to thorax) legs from labial palps and maxillary palps that display malformation or smaller size.[3]

References
  1. Brody TB (1996). "Proboscipedia". Interactive Fly, Drosophila. Archived from the original on 2016-03-04. Retrieved 1 April 2015.
  2. dos Santos G, Schroeder AJ, Goodman JL, Strelets VB, Crosby MA, Thurmond J, et al. (January 2015). "FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations". Nucleic Acids Research. 43 (Database issue): D690-7. doi:10.1093/nar/gku1099. PMC 4383921. PMID 25398896.
  3. Spirov A (April 2015). "Proboscipedia: Drosophila/Vertebrate Genes in Development: Drosophila Antp-like HOM-gen". HOX Pro db. Archived from the original on 2016-02-25.
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