Procyclin

Procyclins also known as procyclic acidic repetitive proteins or PARP[1] are proteins developed in the surface coating of Trypanosoma brucei parasites while in their tsetse fly vector.[2] The cell surface of the bloodstream form features a dense coat of variable surface glycoproteins (VSGs) which is replaced by an equally dense coat of procyclins when the parasite differentiates into the procylic form in the tsetse fly midgut.

Procyclic acidic repetitive
Identifiers
Symbol?
PfamPF05887
InterProIPR008882
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
EP1 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolTb10.6k15.0020
Entrez3661797
RefSeq (mRNA)XM_818154.1
RefSeq (Prot)XP_823247.1
UniProtQ389V1
Other data
Chromosome10: 2.48 - 2.48 Mb
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StructuresSwiss-model
DomainsInterPro
Surface protein EP1-2 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolEP1-2
UniProtQ7KG35
Search for
StructuresSwiss-model
DomainsInterPro
EP2 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolTb10.6k15.0030
Entrez3661534
RefSeq (mRNA)XM_818153.1
RefSeq (Prot)XP_823246.1
UniProtQ389V2
Other data
Chromosome10: 2.48 - 2.48 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Surface protein EP2-1 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolEP2-1
UniProtQ95PJ2
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StructuresSwiss-model
DomainsInterPro
Procyclin EP3
Identifiers
OrganismTrypanosoma brucei
SymbolEP3
UniProtQ86MA3
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StructuresSwiss-model
DomainsInterPro
EP3-2 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolTb927.6.520
Entrez3657688
RefSeq (mRNA)XM_840082.1
RefSeq (Prot)XP_845175.1
UniProtQ581F6
Other data
Chromosome6: 0.23 - 0.23 Mb
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StructuresSwiss-model
DomainsInterPro
Surface protein EP3-3 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolEP3-3
UniProtQ95NW2
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StructuresSwiss-model
DomainsInterPro
Surface protein EP3-4 procyclin
Identifiers
OrganismTrypanosoma brucei
SymbolEP3-4
UniProtQ95PJ3
Search for
StructuresSwiss-model
DomainsInterPro
GPEET2 procyclin precursor
Identifiers
OrganismTrypanosoma brucei
SymbolTb927.6.510, Tb06.28F21.90
Entrez3657686
RefSeq (mRNA)XM_840081.1
RefSeq (Prot)XP_845174.1
UniProtQ581F9
Other data
Chromosome6: 0.23 - 0.23 Mb
Search for
StructuresSwiss-model
DomainsInterPro

There are six or seven procyclin genes that encode unusual proteins with extensive tandem repeat units of glutamic acid (E) and proline (P), referred to as EP repeats (EP1, EP1-2, EP2, EP2-1, EP3, EP3-2, EP3-4), and two genes that encode proteins with internal pentapeptide GPEET repeats (GPEET2).[3]

EP1 is a 141 amino acids protein and EP2 is a 129 AA protein. Both proteins have their coding genes situated on chromosome 10. GPEET2 is a 114 AA protein and EP3-2 is 123 AA protein with genes situated on chromosome 6.

See also

References
  1. Rudenko G, Le Blancq S, Smith J, Lee MG, Rattray A, Van der Ploeg LH (July 1990). "Procyclic acidic repetitive protein (PARP) genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient DNA transfection of Trypanosoma brucei". Mol. Cell. Biol. 10 (7): 3492–504. doi:10.1128/MCB.10.7.3492. PMC 360784. PMID 1694012.
  2. Acosta-Serrano A, Vassella E, Liniger M, Kunz Renggli C, Brun R, Roditi I, Englund PT (February 2001). "The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1513–8. Bibcode:2001PNAS...98.1513A. doi:10.1073/pnas.98.4.1513. PMC 29288. PMID 11171982.
  3. Bütikofer P, Ruepp S, Boschung M, Roditi I (September 1997). "'GPEET' procyclin is the major surface protein of procyclic culture forms of Trypanosoma brucei brucei strain 427". Biochem. J. 326 (2): 415–23. doi:10.1042/bj3260415. PMC 1218686. PMID 9291113.
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