Protein-histidine N-methyltransferase

In enzymology, a protein-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + protein L-histidine S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
protein-histidine N-methyltransferase
Identifiers
EC no.2.1.1.85
CAS no.108022-17-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and protein L-histidine, whereas its two products are S-adenosylhomocysteine and protein Ntau-methyl-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase. Other names in common use include protein methylase IV, protein (histidine) methyltransferase, actin-specific histidine methyltransferase, and S-adenosyl methionine:protein-histidine N-methyltransferase.

References

    • Vijayasarathy C, Rao BS (1987). "Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle". Biochim. Biophys. Acta. 923 (1): 156–65. doi:10.1016/0304-4165(87)90139-5. PMID 3801515.


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