Protein phosphatase with ef-hand domain 2

PPEF2
Identifiers
Aliases	PPEF2, PPP7CB, protein phosphatase with EF-hand domain 2
External IDs	OMIM: 602256 MGI: 1342304 HomoloGene: 55959 GeneCards: PPEF2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	75,902,571 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	92,404,137 bp[2]
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right uterine tube; ; left uterine tube; ; monocyte; ; spleen; ; tibial nerve; ; right coronary artery; ; canal of the cervix; ; skin of abdomen; ; lymph node;
	Top expressed in
	retinal pigment epithelium; ; pineal gland; ; morula; ; secondary oocyte; ; primitive streak; ; yolk sac; ; blastocyst; ; superior frontal gyrus; ; lip; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; Hsp90 protein binding; calcium ion binding; phosphoprotein phosphatase activity; manganese ion binding; mitogen-activated protein kinase kinase kinase binding; protein serine/threonine phosphatase activity; metal ion binding; Hsp70 protein binding; hydrolase activity; protein binding;
Cellular component	cytoplasm; cell projection; photoreceptor inner segment; photoreceptor outer segment; cilium; cytosol; nucleus;
Biological process	detection of stimulus involved in sensory perception; response to stimulus; negative regulation of peptidyl-threonine phosphorylation; protein dephosphorylation; negative regulation of MAPK cascade; regulation of MAP kinase activity; visual perception; regulation of JUN kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5470
	19023
	ENSG00000156194
	ENSMUSG00000029410
	O14830
	O35385
	NM_006239; NM_152933; NM_152934
	NM_011148
	NP_006230
	NP_035278
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase with EF-hand domain 2 is a protein that in humans is encoded by the PPEF2 gene. [5]

Function

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008].

References

GRCh38: Ensembl release 89: ENSG00000156194 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029410 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Protein phosphatase with EF-hand domain 2". Retrieved 2018-02-08.

Protein phosphatase with ef-hand domain 2

Function

References

Further reading