Pseudotropine acyltransferase
Pseudotropine acyltransferase (EC 2.3.1.186, pseudotropine:acyl-CoA transferase, tigloyl-CoA:pseudotropine acyltransferase, acetyl-CoA:pseudotropine acyltransferase, pseudotropine acetyltransferase, pseudotropine tigloyltransferase, PAT) is an enzyme with systematic name acyl-CoA:pseudotropine O-acyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- acyl-CoA + pseudotropine CoA + O-acylpseudotropine
| Pseudotropine acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.186 | ||||||||
| CAS no. | 162535-26-4&title= 138440-78-5, 162535-26-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme exhibits absolute specificity for the exo/3beta configuration found in pseudotropine as tropine (tropan-3alpha-ol).
References
- Rabot S, Peerless AC, Robins RJ (1995). "Tigloyl-CoA:pseudotropine acyltransferase — an enzyme of tropane alkaloid biosynthesis". Phytochemistry. 39 (2): 315–322. doi:10.1016/0031-9422(94)00907-b.
- Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y (November 1991). "The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases". FEBS Letters. 292 (1–2): 293–7. doi:10.1016/0014-5793(91)80887-9. PMID 1959620.
- Robins RJ, Bachmann P, Peerless AC (1994). "Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures". Plant Cell Tissue Organ Cult. 38 (2–3): 241–247. doi:10.1007/bf00033883. S2CID 21524758.
- Boswell HD, Dräger B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ (November 1999). "Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura". Phytochemistry. 52 (5): 871–8. doi:10.1016/S0031-9422(99)00293-9. PMID 10626376.
External links
- Pseudotropine+acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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