Tinnitus

Tinnitus is a variety of sound that is heard when no corresponding external sound is present.[1] Nearly everyone experiences faint "normal tinnitus" in a completely quiet room; but it is of concern only if it is bothersome, interferes with normal hearing, or is associated with other problems.[6] The word tinnitus comes from the Latin tinnire, "to ring".[3] In some people, it interferes with concentration, and can be associated with anxiety and depression.[7][8]

For the Norwegian radio show, see Tinitus (radio show).

Tinnitus
Pronunciation
  • /ˈtɪnɪtəs/ or /tɪˈnaɪtəs/
SpecialtyOtorhinolaryngology, audiology
SymptomsHearing sound when no external sound is present[1]
ComplicationsPoor concentration, anxiety, depression[2]
Usual onsetGradual[3]
CausesNoise-induced hearing loss, ear infections, disease of the heart or blood vessels, Ménière's disease, brain tumors, inner ear tumors, emotional stress, traumatic brain injury, excessive earwax[2][4]
Diagnostic methodBased on symptoms, audiogram, neurological exam[1][3]
TreatmentCounseling, sound generators, hearing aids[2][5]
Frequency~12.5%[5]

Tinnitus is usually associated with hearing loss and decreased comprehension of speech in noisy environments.[2] It is common, affecting about 10–15% of people. Most tolerate it well, and it is a significant problem in only 1–2% of people.[5] It can trigger a fight-or-flight response, as the brain may perceive it as dangerous and important.[9][10][11]

Rather than a disease, tinnitus is a symptom that may result from a variety of underlying causes and may be generated at any level of the auditory system as well as outside that system. The most common causes are hearing damage, noise-induced hearing loss, or age-related hearing loss, known as presbycusis.[2] Other causes include ear infections, disease of the heart or blood vessels, Ménière's disease, brain tumors, acoustic neuromas (tumors on the auditory nerves of the ear), migraines, temporomandibular joint disorders, exposure to certain medications, a previous head injury, and earwax. It can suddenly emerge during a period of emotional stress.[4][3][2][12][13] It is more common in those with depression.[3]

The diagnosis of tinnitus is usually based on a patient's description of the symptoms they are experiencing.[3] Such a diagnosis is commonly supported by an audiogram, and an otolaryngological and neurological examination.[1][3] How much tinnitus interferes with a person's life may be quantified with questionnaires.[3] If certain problems are found, medical imaging, such as magnetic resonance imaging (MRI), may be performed. Other tests are suitable when tinnitus occurs with the same rhythm as the heartbeat.[3] Rarely, the sound may be heard by someone other than the patient by using a stethoscope, in which case it is known as "objective tinnitus."[3] Occasionally, spontaneous otoacoustic emissions, sounds produced normally by the inner ear, may result in tinnitus.[14]

Measures to prevent tinnitus include avoiding chronic or extended exposure to loud noise, and limiting exposure to ototoxic drugs and substances.[2][15] If there is an underlying cause, treating that cause may lead to improvements.[3] Otherwise, typically, tinnitus management involves psychoeducation or counseling, such as talk therapy.[5] Sound generators or hearing aids may help.[2] No medication directly targets tinnitus.

Signs and symptoms

Tinnitus is often described as ringing, but it may also sound like clicking, buzzing, hissing, or roaring.[4] It may be soft or loud, low- or high-pitched, and may seem to come from either one or both ears, or from the head itself. It may be intermittent or continuous. In some individuals, its intensity may be changed by shoulder, neck, head, tongue, jaw, or eye movements.[16]

Course

Due to variations in study designs, data on the course of tinnitus shows few consistent results. Generally, prevalence increases with age in adults, and the ratings of annoyance decreases with duration.[17][18][19]

Psychological effects

Although it is an annoying condition to which most people adapt, persistent tinnitus may cause anxiety and depression in some people.[20][21] Tinnitus annoyance is more strongly associated with the psychological condition of the person than the loudness or frequency range of the perceived sound.[22][23] Psychological problems such as depression, anxiety, sleep disturbances, and concentration difficulties are common in those with strongly annoying tinnitus.[24][25] 45% of people with tinnitus have an anxiety disorder at some time in their lives.[26]

Psychological research has focused on the tinnitus distress reaction to account for differences in tinnitus severity.[24][27][28][29] The research indicates that conditioning at the initial perception of tinnitus linked it with negative emotions, such as fear and anxiety.[30]

Types

Commonly tinnitus is classified into "subjective and objective tinnitus".[3] Tinnitus is usually subjective, meaning that the sounds the person hears are not detectable by means currently available to physicians and hearing technicians.[3] Subjective tinnitus has also been called "tinnitus aurium", "non-auditory", or "non-vibratory" tinnitus. In rare cases, tinnitus can be heard by someone else using a stethoscope. Even more rarely, in some cases it can be measured as a spontaneous otoacoustic emission (SOAE) in the ear canal. This is classified as objective tinnitus,[3] also called "pseudo-tinnitus" or "vibratory" tinnitus.

Subjective tinnitus

Subjective tinnitus is the most frequent type. It can have many causes, but most commonly it results from hearing loss. When it is caused by disorders of the inner ear or auditory nerve, it can be called "otic" (from the Greek word for ear).[31] These otological or neurological disorders include those triggered by infections, drugs, or trauma.[32] A frequent cause is traumatic noise exposure that damages hair cells in the inner ear.. Some evidence suggests that long-term exposure to noise pollution from heavy traffic may increase the risk of developing tinnitus.[33]

When there does not seem to be a connection with a disorder of the inner ear or auditory nerve, tinnitus can be called "non-otic". In 30% of cases, tinnitus is influenced by the somatosensory system; for instance, people can increase or decrease their tinnitus by moving their face, head, jaw, or neck.[34] This type is called somatic or craniocervical tinnitus, since it is only head or neck movements that have an effect.[31]

Some tinnitus may be caused by neuroplastic changes in the central auditory pathway. In this theory, the disturbance of sensory input caused by hearing loss results in such changes[35] as a homeostatic response of neurons in the central auditory system, causing tinnitus.[36] When some frequencies of sound are lost to hearing loss, the auditory system compensates by amplifying those frequencies, eventually producing sound sensations at those frequencies constantly even when there is no corresponding external sound.

Hearing loss

The most common cause of tinnitus is hearing loss. Hearing loss may have many different causes, but among those with tinnitus, the major cause is cochlear injury.[35]

In many cases no underlying cause is identified.[2][37]

Ototoxic drugs also may cause subjective tinnitus, as they may cause hearing loss,[15] or increase the damage done by exposure to loud noise.[38] This damage may occur even at doses not considered ototoxic.[39] More than 260 medications have been reported to cause tinnitus as a side effect.[40]

Tinnitus can also occur from the discontinuation of therapeutic doses of benzodiazepines. It can sometimes be a protracted symptom of benzodiazepine withdrawal and may persist for many months.[41][42] Medications such as bupropion may also cause tinnitus.[43]

Associated factors

Factors associated with tinnitus include:[44]

Objective tinnitus

A specific type of tinnitus, objective tinnitus, is characterized by hearing the sounds of one's own muscle contractions or pulse, typically a result of sounds that have been created by the movement of jaw muscles or sounds related to blood flow in the neck or face.[49] It is sometimes caused by an involuntary twitching of a muscle or a group of muscles (myoclonus) or by a vascular condition. In some cases, tinnitus is generated by muscle spasms around the middle ear.[49]

Spontaneous otoacoustic emissions (SOAEs)—faint high-frequency tones that are produced in the inner ear and can be measured in the ear canal with a sensitive microphone—may also cause tinnitus.[14] About 8% of those with SOAEs and tinnitus have SOAE-linked tinnitus, while the percentage of all cases of tinnitus caused by SOAEs is estimated at 4%.[14]

Pediatric tinnitus

Children may be subject to pulsatile or continuous tinnitus, involving anomalies and variants of the vascular parts[50] affecting the middle/inner ear structures. CT scans may be used to check the integrity of the structures, and MR scans can evaluate nerves and potential masses or malformations. Early diagnosis can prevent long-term impairments to development.[51]

Pulsatile tinnitus

Some people experience a sound that beats in time with their pulse, known as pulsatile tinnitus or vascular tinnitus.[52] Pulsatile tinnitus is usually objective in nature, resulting from altered blood flow or increased blood turbulence near the ear, such as from atherosclerosis or venous hum,[53] but it can also arise as a subjective phenomenon from an increased awareness of blood flow in the ear.[52] Rarely, pulsatile tinnitus may be a symptom of potentially life-threatening conditions such as carotid artery aneurysm[54] or carotid artery dissection.[55] Pulsatile tinnitus may also indicate vasculitis, or more specifically, giant cell arteritis. Pulsatile tinnitus may also indicate idiopathic intracranial hypertension.[56] Pulsatile tinnitus can be a symptom of intracranial vascular abnormalities and should be evaluated for irregular noises of blood flow (bruits).[57]

Pathophysiology

Tinnitus may be caused by increased neural activity in the auditory brainstem, where the brain processes sounds, causing some auditory nerve cells to become overexcited. The basis of this theory is that many with tinnitus also have hearing loss.[58]

Three reviews in 2016 emphasized the large range and possible combinations of pathologies involved in tinnitus, which result in a great variety of symptoms and specifically adapted therapies.[59][60][61][62]

Diagnosis

The diagnostic approach is based on a history of the condition and an examination of the head, neck, and neurological system.[37] Typically an audiogram is done, and occasionally medical imaging or electronystagmography.[37] Treatable conditions may include middle ear infection, acoustic neuroma, concussion, and otosclerosis.[63]

Evaluation of tinnitus can include a hearing test (audiogram), measurement of acoustic parameters of the tinnitus like pitch and loudness, and psychological assessment of comorbid conditions like depression, anxiety, and stress that are associated with severity of the tinnitus.

One definition of tinnitus, in contrast to normal ear noise experience, is that tinnitus lasts five minutes at least twice a week.[64] However, people with tinnitus often experience the noise more frequently than this. Tinnitus can be present constantly or intermittently. Some people with constant tinnitus might not be aware of it all the time, but only, for example, during the night when there is less environmental noise to mask it. Chronic tinnitus can be defined as tinnitus with a duration of six months or more.[65]

Audiology

Since most people with tinnitus also have hearing loss, a pure tone hearing test resulting in an audiogram may help diagnose a cause. An audiogram may also facilitate fitting of a hearing aid in those cases where hearing loss is significant. The pitch of tinnitus is often in the range of the hearing loss.

Psychoacoustics

Acoustic qualification of tinnitus includes measurement of several acoustic parameters like frequency in cases of monotone tinnitus or frequency range and bandwidth in cases of narrow band noise tinnitus, loudness in dB above hearing threshold at the indicated frequency, mixing-point, and minimum masking level.[66] In most cases, tinnitus pitch or frequency range is between 5 kHz and 10 kHz,[67] and loudness between 5 and 15 dB above the hearing threshold.[68]

Another relevant parameter of tinnitus is residual inhibition: the temporary suppression or disappearance of tinnitus following a period of masking. The degree of residual inhibition may indicate how effective tinnitus maskers would be as treatment.[69][70]

An assessment of hyperacusis, a frequent accompaniment of tinnitus,[71] may also be made.[72] Hyperacusis is related to negative reactions to sound and can take many forms. One parameter that can be measured is Loudness Discomfort Level (LDL) in dB, the subjective level of acute discomfort at specified frequencies over the frequency range of hearing. This defines a dynamic range between the hearing threshold at that frequency and the loudness discomfort level. A compressed dynamic range over a particular frequency range can be associated with hyperacusis. Normal hearing threshold is generally defined as 0–20 decibels (dB). Normal loudness discomfort levels are 85–90+ dB, with some authorities citing 100 dB. A dynamic range of 55 dB or less is indicative of hyperacusis.[73][74]

Severity

Tinnitus is often rated on a scale from "slight" to "severe" according to the effects it has, such as interference with sleep, quiet activities, and normal daily activities.[75]

Assessment of psychological processes related to tinnitus involves measurement of tinnitus severity and distress, as measured subjectively by validated self-report tinnitus questionnaires.[24] Such questionnaires measure the degree of psychological distress and handicap associated with tinnitus, including effects on hearing, lifestyle, health, and emotional functioning.[76][77][78] A broader assessment of general functioning, such as levels of anxiety, depression, stress, life stressors, and sleep difficulties, is also important in the assessment of tinnitus due to higher risk of negative well-being across these areas, which may be affected by or exacerbate the tinnitus symptoms.[79] Current assessment measures aim to identify levels of distress and interference, coping responses, and perceptions of tinnitus to inform treatment and monitor progress. However, wide variability, inconsistencies, and lack of consensus regarding assessment methodology are evidenced in the literature, limiting comparison of treatment effectiveness.[80] Developed to guide diagnosis or classify severity, most tinnitus questionnaires have been shown to be treatment-sensitive outcome measures.[81]

Pulsatile tinnitus

If examination reveals a bruit (sound due to turbulent blood flow), imaging studies such as transcranial doppler (TCD) or magnetic resonance angiography (MRA) should be performed.[82][83][84]

Differential diagnosis

Other potential sources of the sounds normally associated with tinnitus should be ruled out. For instance, two recognized sources of high-pitched sounds might be electromagnetic fields common in modern wiring and various sound signal transmissions. A common and often misdiagnosed condition that mimics tinnitus is radio frequency (RF) hearing, in which subjects hear objectively audible high-pitched transmission frequencies that sound similar to tinnitus.[85][86]

Prevention
Safety sign from the UK Government Regulations requiring ear protection

Prolonged exposure to loud sound or noise levels can lead to tinnitus.[87] Custom made ear plugs or other measures can help with prevention. Employers may use hearing loss prevention programs to help educate and prevent dangerous levels of exposure to noise. Government organizations set regulations to ensure employees, if following the protocol, should have minimal risk to permanent damage to their hearing.[88]

Certain groups are advised to wear ear plugs to avoid the risk of tinnitus, such as that caused by overexposure to loud noises like wind noise for motorcycle riders.[89] This includes military personnel,[38] musicians,[90] DJs,[91] agricultural workers,[92] and construction workers [93] as people in those occupations are at a greater risk compared to the general population.

Several medicines have ototoxic effects, which can have a cumulative effect that increases the damage done by noise.[38] If ototoxic medications must be administered, close attention by the physician to prescription details, such as dose and dosage interval, can reduce the damage done.[15][94][95][96]

Management

If a specific underlying cause is determined, treating it may lead to improvements.[3] Otherwise, the primary treatment for tinnitus is talk therapy,[5] sound therapy, or hearing aids. There are no effective drugs that treat tinnitus.[3][97][98]

Psychological

The best-supported treatment for tinnitus is cognitive behavioral therapy (CBT).[5][81][99] It decreases the stress those with tinnitus feel.[100] This appears to be independent of any effect on depression or anxiety.[99] Acceptance and commitment therapy (ACT) also shows promise in the treatment of tinnitus.[101] Relaxation techniques may also help.[3] A clinical protocol called Progressive Tinnitus Management has been developed by the United States Department of Veterans Affairs.[102]

Sound-based interventions

The application of sound therapy by either hearing aids or tinnitus maskers may help the brain ignore the specific tinnitus frequency. Although these methods are poorly supported by evidence, there are no negative effects.[3][103][104] There are several approaches for tinnitus sound therapy. The first is sound modification to compensate for the individual's hearing loss. The second is a signal spectrum notching to eliminate energy close to the tinnitus frequency.[105][106] There is some tentative evidence supporting tinnitus retraining therapy, which aims to reduce tinnitus-related neuronal activity.[3][107][106] An alternative tinnitus treatment uses mobile applications that include various methods including masking, sound therapy, and relaxation exercises.[108][109] Such applications can work as a separate device or as a hearing aid control system.[110]

Neuromonics is another sound-based intervention. Its protocol follows the principle of systematic desensitization and involves a structured rehabilitation program lasting 12 months. Neuromonics therapy employs customized sound signals delivered through a device worn by the patient, which aims to target the specific frequency range associated with their tinnitus perception.[111]

Medications

As of 2018 there were no medications effective for idiopathic tinnitus.[3][87][112] There is not enough evidence to determine if antidepressants[113] or acamprosate are useful.[114] There is no high-quality evidence to support the use of benzodiazepines for tinnitus.[3][112][115] Usefulness of melatonin, as of 2015, is unclear.[116] It is unclear if anticonvulsants are useful for treating tinnitus.[3][117] Steroid injections into the middle ear also do not seem to be effective.[118][119] There is no evidence to suggest that the use of betahistine to treat tinnitus is effective.[120]

Botulinum toxin injection has succeeded in some of the rare cases of objective tinnitus from a palatal tremor.[121]

Caroverine is used in a few countries to treat tinnitus.[122] The evidence for its usefulness is very weak.[123]

Neuromodulation

In 2020, information about clinical trials indicated that bimodal neuromodulation may reduce the symptoms of tinnitus. It is a noninvasive technique that involves applying an electrical stimulus to the tongue while also administering sounds.[124] Equipment associated with the treatments is available through physicians. Studies with it and similar devices continue in several research centers.

Some evidence supports neuromodulation techniques such as transcranial magnetic stimulation,[3][125] transcranial direct current stimulation, and neurofeedback.

Alternative medicine

Ginkgo biloba does not appear to be effective.[112][126] The American Academy of Otolaryngology recommends against taking melatonin or zinc supplements to relieve symptoms of tinnitus, and reported that evidence for the efficacy of many dietary supplements (such as lipoflavonoids, garlic, traditional Chinese/Korean herbal medicine, honeybee larvae, and various other vitamins and minerals, as well as homeopathic preparations) did not exist.[87] A 2016 Cochrane Review also concluded that evidence was not sufficient to support taking zinc supplements to reduce symptoms associated with tinnitus.[127]

Prognosis

While there is no cure, most people with tinnitus get used to it over time; for a minority, it remains a significant problem.[5]

Epidemiology

Adults

Tinnitus affects 10–15% of people.[5] About a third of North Americans over 55 experience it.[128] It affects one third of adults at some time in their lives, whereas 10–15% are disturbed enough to seek medical evaluation.[129] 70 million people in Europe are estimated to have tinnitus.[130][131]

Children

Tinnitus is commonly thought of as a symptom of adulthood, and is often overlooked in children. Children with hearing loss have a high incidence of pediatric tinnitus, even though they do not express the condition or its effect on their lives.[132][133] Children do not generally report tinnitus spontaneously and their complaints may not be taken seriously.[134] Among those who do complain, there is an increased likelihood of associated otological or neurological pathology such as migraine, juvenile Meniere's disease, or chronic suppurative otitis media.[135] Its reported prevalence varies from 12 to 36% in children with normal hearing thresholds, and up to 66% in children with a hearing loss. Approximately 3–10% of children have been reported to be troubled by tinnitus.[136]

See also

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