Purine imidazole-ring cyclase

The enzyme purine imidazole-ring cyclase (EC 4.3.2.4) catalyzes the chemical reaction

DNA 4,6-diamino-5-formamidopyrimidine DNA adenine + H2O
purine imidazole-ring cyclase
Identifiers
EC no.4.3.2.4
CAS no.95990-28-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, DNA-adenine-forming).

References

    • Chetsanga CJ, Grigorian C (1985). "In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by γ-irradiation". Proc. Natl. Acad. Sci. U.S.A. 82 (3): 633–7. Bibcode:1985PNAS...82..633C. doi:10.1073/pnas.82.3.633. PMC 397099. PMID 3856219.


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