Putrescine oxidase

In enzymology, a putrescine oxidase (EC 1.4.3.10) is an enzyme that catalyzes the chemical reaction

putrescine + O2 + H2O 4-aminobutanal + NH3 + H2O2
putrescine oxidase
Identifiers
EC no.1.4.3.10
CAS no.9076-87-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are putrescine, O2, and H2O, whereas its 3 products are 4-aminobutanal, NH3, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with oxygen as acceptor. The systematic name of this enzyme class is putrescine:oxygen oxidoreductase (deaminating). This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, FAD.

References

    • DeSa RJ (September 1972). "Putrescine oxidase from Micrococcus rubens. Purification and properties of the enzyme". The Journal of Biological Chemistry. 247 (17): 5527–34. PMID 4341347.
    • Yamada H (1971). "Putrescine oxidase (Micrococcus rubens)". Methods Enzymol. 17B: 726–730. doi:10.1016/0076-6879(71)17126-1.


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