Pyridine-3-carbaldehyde
Pyridine-3-carbaldehyde, also known as nicotinaldehyde, is an organic compound with the formula C5H4NCHO. It is one of three isomeric pyridinaldehydes. The other isomers are pyridine-2-carboxaldehyde and pyridine-4-carboxaldehyde. It is a colorless liquid that is routinely available commercially. It can be produced from nicotinonitrile. Alternatively, it arises by the aerobic oxidation of the corresponding alcohol.[1]
Names | |
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Preferred IUPAC name
Pyridine-3-carbaldehyde | |
Other names
Nicotinaldehyde, 3-formylpyridine, 3-pyridinaldehyde | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.007.183 |
EC Number |
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KEGG | |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C6H5NO | |
Molar mass | 107.112 g·mol−1 |
Appearance | colorless liquid |
Density | 1.14 g/cm3 |
Melting point | 7 °C (45 °F; 280 K) |
Boiling point | 95–97 °C (203–207 °F; 368–370 K) 15 mm |
Hazards | |
GHS labelling: | |
Danger | |
H226, H302, H315, H317, H318, H334, H335, H341, H412 | |
P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P272, P273, P280, P281, P285, P301+P312, P302+P352, P303+P361+P353, P304+P340, P304+P341, P305+P351+P338, P308+P313, P310, P312, P321, P330, P332+P313, P333+P313, P342+P311, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references |
Safety
3-Pyridinecarboxaldehyde is a severe skin irritant.[2]
References
- Marko, I. E.; Giles, P. R.; Tsukazaki, M.; Brown, S. M.; Urch, C. J. (1996). "Copper-Catalyzed Oxidation of Alcohols to Aldehydes and Ketones: An Efficient, Aerobic Alternative". Science. 274 (5295): 2044–2046. Bibcode:1996Sci...274.2044M. doi:10.1126/science.274.5295.2044. PMID 8953027. S2CID 23952453.
- H. Stetter1, H. Kuhlmann, and G. Lorenz (1979). "Cyanide-Catalyzed Conjugate Addition of Aryl Aldehydes: 4-Oxo-4-(3-Pyridyl)Butyronitrile". Organic Syntheses. 59: 53. doi:10.15227/orgsyn.059.0053.
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