Pyridine-N-oxide

Pyridine-N-oxide is the heterocyclic compound with the formula C5H5NO. This colourless, hygroscopic solid is the product of the oxidation of pyridine. It was originally prepared using peroxyacids as the oxidising agent. The compound is used infrequently as an oxidizing reagent in organic synthesis.[1]

Pyridine-N-oxide
Skeletal formula
Ball-and-stick model
Names
Preferred IUPAC name
1λ5-Pyridin-1-one
Other names
Pyridine-1-oxide
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.010.705
UNII
  • InChI=1S/C5H5NO/c7-6-4-2-1-3-5-6/h1-5H checkY
    Key: ILVXOBCQQYKLDS-UHFFFAOYSA-N checkY
  • InChI=1/C5H5NO/c7-6-4-2-1-3-5-6/h1-5H
    Key: ILVXOBCQQYKLDS-UHFFFAOYAZ
  • c1cc[n+](cc1)[O-]
Properties
C5H5NO
Molar mass 95.101 g·mol−1
Appearance Colourless solid
Melting point 65 to 66 °C (149 to 151 °F; 338 to 339 K)
Boiling point 270 °C (518 °F; 543 K)
high
Acidity (pKa) 0.8 (of conjugate acid)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Structure

The structure of pyridine-N-oxide is very similar to that of pyridine with respect to the parameters for the ring. The molecule is planar. The N-O distance is 1.34 Å. The C-N-C angle is 124°, 7° wider than in pyridine.[2]

Synthesis

The oxidation of pyridine can be achieved with a number of peracids including peracetic acid and perbenzoic acid.[3] Oxidation can also be effected by a modified Dakin reaction using a urea-hydrogen peroxide complex,[4] and sodium perborate[5] or, using methylrhenium trioxide (CH
3ReO
3) as catalyst, with sodium percarbonate.[6]

Reactions

Pyridine N-oxide is five orders of magnitude less basic than pyridine: the pKa of protonated pyridine-N-oxide is 0.8.[7] Protonated derivatives are isolable, e.g., [C5H5NOH]Cl.[3] Further demonstrating its (feeble) basicity, pyridine-N-oxide also serves as a ligand in coordination chemistry. A host of transition metal complexes of pyridine-N-oxides are known.

Treatment of the pyridine-N-oxide with phosphorus oxychloride gives 4- and 2-chloropyridines.[8]

The N-oxides of various pyridines are precursors to useful drugs:[9]

Safety

The compound is a skin irritant.[1]

Further reading
  • discovery of pyridine-N-oxide: Meisenheimer, Jakob (1926). "Über Pyridin-, Chinolin- und Isochinolin-N-oxyd". Ber. Dtsch. Chem. Ges. (in German). 59 (8): 1848–1853. doi:10.1002/cber.19260590828.
  • Synthesis of N-oxides from substituted pyridines: Youssif, Shaker (2001). "Recent trends in the chemistry of pyridine N-oxides". Arkivoc. 2001: 242–268. doi:10.3998/ark.5550190.0002.116.

References
  1. Kilényi, S. Nicholas; Mousseau, James J. (20 September 2015). "PyridineN-Oxide". Pyridine N-Oxide. Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons. pp. 1–6. doi:10.1002/047084289X.rp283.pub2. ISBN 9780470842898.
  2. Ülkü, D.; Huddle, B. P.; Morrow, J. C. (1971). "The Crystal Structure of Pyridine 1-oxide". Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry. 27 (2): 432–436. doi:10.1107/S0567740871002334.
  3. Mosher, H. S.; Turner, L.; Carlsmith, A. (1953). "Pyridine-N-oxide". Org. Synth. 33: 79. doi:10.15227/orgsyn.033.0079.
  4. Varma, Rajender S.; Naicker, Kannan P. (1999). "The Urea−Hydrogen Peroxide Complex: Solid-State Oxidative Protocols for Hydroxylated Aldehydes and Ketones (Dakin Reaction), Nitriles, Sulfides, and Nitrogen Heterocycles". Org. Lett. 1 (2): 189–192. doi:10.1021/ol990522n.
  5. McKillop, Alexander; Kemp, Duncan (1989). "Further functional group oxidations using sodium perborate". Tetrahedron. 45 (11): 3299–3306. doi:10.1016/S0040-4020(01)81008-5.
  6. Jain, Suman L.; Joseph, Jomy K.; Sain, Bir (2006). "Rhenium-Catalyzed Highly Efficient Oxidations of Tertiary Nitrogen Compounds to N-Oxides Using Sodium Percarbonate as Oxygen Source". Synlett. 2006 (16): 2661–2663. doi:10.1055/s-2006-951487.
  7. Chmurzyński, L. (1996). "Studies on correlations of acid-base properties of substituted pyridine N-oxides in solutions. Part 1. Correlations of the p Ka values in non-aqueous solvents and water". Analytica Chimica Acta. 321 (2–3): 237–244. doi:10.1016/0003-2670(95)00594-3.
  8. Scriven, E. F. V. (1984). "Pyridines and their Benzo Derivatives: (ii) Reactivity at Ring Atoms". In Katritzky, Alan R.; Rees, Charles Wayne; Meth-Cohn, Otto (eds.). Comprehensive Heterocyclic Chemistry: The Structure, Reactions, Synthesis and Uses of Heterocyclic Compounds. Vol. 2. Pergamon Press. pp. 165–314. doi:10.1016/B978-008096519-2.00027-8. ISBN 9780080307015.
  9. Shimizu, Shinkichi; Watanabe, Nanao; Kataoka, Toshiaki; Shoji, Takayuki; Abe, Nobuyuki; Morishita, Sinji; Ichimura, Hisao (2000). Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a22_399.
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