QRFP

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.[5]

QRFP
Identifiers
AliasesQRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDsOMIM: 609795 MGI: 3630329 HomoloGene: 52341 GeneCards: QRFP
Orthologs
SpeciesHumanMouse
Entrez

347148

227717

Ensembl

ENSG00000188710

ENSMUSG00000043102

UniProt

P83859

Q8CE23

RefSeq (mRNA)

NM_198180

NM_183424

RefSeq (protein)

NP_937823

NP_906269

Location (UCSC)Chr 9: 130.89 – 130.9 MbChr 2: 31.7 – 31.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000188710 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000043102 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
  6. Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
  7. Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.

Further reading


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