QSOX1

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene.[5][6][7]

QSOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesQSOX1, Q6, QSCN6, quiescin sulfhydryl oxidase 1
External IDsOMIM: 603120 MGI: 1330818 HomoloGene: 37690 GeneCards: QSOX1
Orthologs
SpeciesHumanMouse
Entrez

5768

104009

Ensembl

ENSG00000116260

ENSMUSG00000033684

UniProt

O00391

Q8BND5

RefSeq (mRNA)

NM_002826
NM_001004128

NM_001024945
NM_023268

RefSeq (protein)

NP_001004128
NP_002817

NP_001020116
NP_075757

Location (UCSC)Chr 1: 180.15 – 180.2 MbChr 1: 155.65 – 155.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000116260 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033684 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Coppock DL, Cina-Poppe D, Gilleran S (Feb 1999). "The quiescin Q6 gene (QSCN6) is a fusion of two ancient gene families: thioredoxin and ERV1". Genomics. 54 (3): 460–8. doi:10.1006/geno.1998.5605. PMID 9878249.
  6. Coppock DL, Kopman C, Scandalis S, Gilleran S (Oct 1993). "Preferential gene expression in quiescent human lung fibroblasts". Cell Growth Differ. 4 (6): 483–93. PMID 8396966.
  7. "Entrez Gene: QSCN6 quiescin Q6".

Further reading

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