Quentin Gibson

Quentin Howieson Gibson FRS[1] (9 December 1918 – 16 March 2011) was a Scottish American physiologist, and professor at the University of Sheffield,[3] and Cornell University.[4]

Professor Quentin Gibson
Born
Quentin Howieson Gibson

(1918-12-09)9 December 1918
Aberdeen, Scotland
Died6 March 2011(2011-03-06) (aged 92)
CitizenshipBritish, American
EducationQueen's University Belfast
SpouseAudrey Jane Pinsent
Children4
AwardsFellow of the Royal Society (1969)[1]
Scientific career
FieldsBiochemistry of heme proteins
InstitutionsUniversity of Sheffield
Cornell University
University of Pennsylvania
Notable studentsKeith Moffat[2]

Education

Gibson earned a Doctor of Medicine degree in 1944 and a Ph.D. in 1946, from Queen's University Belfast.

Life

Gibson taught at the University of Sheffield from 1947. Whilst at the University of Sheffield Gibson met Audrey Jane Pinsent in 1951. They married, started a family, and eventually had four children. Jane Gibson continued working part-time whilst raising her family. In 1963 they emigrated to the United States, where she took up positions, first at the University of Pennsylvania.[5] He succeeded (Sir) Hans Krebs as the Head of the Department of Biochemistry in 1955. In 1963 he left Sheffield to become a professor at the University of Pennsylvania. He was the Greater Philadelphia Professor at Cornell University, from 1965 to 1996. In 1982, he became a U.S. citizen.[6]

Research

Hemoglobin

Gibson started his career with studies of hemoglobin,[7] [8] and continued with much other work on heme proteins.

Medical and physiological work

In keeping with his medical qualifications, much of Gibson's early work[9] [10] had medical or physiological relevance.[11]

Cooperativity

During the period when protein and enzyme cooperativity was at the center of biochemical interest Gibson studied it in the context of abnormal hemoglobins.[12] [13]

Rapid reactions

Gibson made major contributions to the development of methods for studying rapid reactions,[14] and their application to hemoglobin.[15]

Other proteins

Other work concerned enzymes such as "diaphorase",[16][17] glucose oxidase,[18] cytochrome oxidase[19][20] and peroxidase.[21]

Thermodynamics

Much of Gibson's work concerned questions of thermodynamics and equilibria, and in that context he participated in discussions about how to present thermodynamic data.[22]

Awards and honours

Gibson was elected a Fellow of the Royal Society in 1969.[1] He was also a member of the National Academy of Sciences, and an associate editor of the Journal of Biological Chemistry from 1975 to 1994.[23]

References
  1. Olson, J. S.; Gutfreund, H. (2013). "Quentin Howieson Gibson 9 December 1918 -- 16 March 2011". Biographical Memoirs of Fellows of the Royal Society. 60: 169–210. doi:10.1098/rsbm.2013.0018.
  2. "Quentin H. Gibson's Profile on Academic Tree".
  3. "Quentin H. Gibson". Cf.ac.uk. Retrieved 21 December 2011.
  4. "Notices 2011". Royal Society. Retrieved 21 December 2011.
  5. Bretscher, Anthony. "Audrey Jane Gibson" (PDF). ecommons.cornell.edu. Cornell University. Retrieved 27 March 2017.
  6. Olson, John. "Retrospective: Quentin H. Gibson". Asbmb.org. Retrieved 21 December 2011.
  7. Gibson, Q. H. (1943). "The reduction of methaemoglobin by ascorbic acid". Biochemical Journal. 37 (5): 615–618. doi:10.1042/bj0370615. PMC 1257979. PMID 16747706.
  8. Gibson, Q. H. (1948). "The reduction of methaemoglobin in red blood cells and studies on the cause of idiopathic methaemoglobinaemia". Biochemical Journal. 42 (1): 13–23. doi:10.1042/bj0420013. PMC 1258588. PMID 16748235.
  9. Gibson, Q. H.; Harrison, D. C.; Montgomery, D. A. D. (1950). "Case of Acute Porphyria". BMJ. 1 (4648): 275–277. doi:10.1136/bmj.1.4648.275. PMC 2036737. PMID 15410128.
  10. Gibson, Q. H.; Wiseman, G. (1951). "Selective absorption of stereo-isomers of amino-acids from loops of the small intestine of the rat". Biochemical Journal. 48 (4): 426–429. doi:10.1042/bj0480426. PMC 1275345. PMID 14838861.
  11. Carey, Francis G.; Gibson, Quentin H. (1987). "Blood Flow in the Muscle of Free-Swimming Fish". Physiological Zoology. 60: 138–148. doi:10.1086/physzool.60.1.30158635. S2CID 87448894.
  12. Cassoly, Robert; Gibson, Quentin H. (1975). "Conformation, co-operativity and ligand binding in human hemoglobin". Journal of Molecular Biology. 91 (3): 301–313. doi:10.1016/0022-2836(75)90382-4. PMID 171411.
  13. Gibson, Q. H.; Roughton, F. J. W. (1957). "The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin". The Journal of Physiology. 136 (3): 507–526. doi:10.1113/jphysiol.1957.sp005777. PMC 1358871. PMID 13429517.
  14. Gibson, QH; Milnes, L. (1964). "Apparatus for rapid and sensitive spectrophotometry". Biochemical Journal. 91 (1): 161–171. doi:10.1042/bj0910161. PMC 1202828. PMID 5833381.
  15. Gibson, Q. H. (1959). "The photochemical formation of a quickly reacting form of haemoglobin". Biochemical Journal. 71 (2): 293–303. doi:10.1042/bj0710293. PMC 1196788. PMID 13628568.
  16. Massey, V.; Gibson, Q. H.; Veeger, C. (1960). "Intermediates in the catalytic action of lipoyl dehydrogenase (Diaphorase)". Biochemical Journal. 77 (2): 341–351. doi:10.1042/bj0770341. PMC 1204990. PMID 13767908.
  17. Gibson, Q. H. (1954). "Stopped-flow apparatus for the study of rapid reactions". Discussions of the Faraday Society. 17: 137. doi:10.1039/df9541700137.
  18. Gibson, Q H; Massey, V; Swoboda, B E P J (1964). "Kinetics and mechanism of action of glucose oxidase". J. Biol. Chem. 239 (11): 3927–3934. doi:10.1016/S0021-9258(18)91224-X. PMID 14257628.
  19. Gibson, Q H; Greenwood, C; Wharton, D C; Palmer, G (1965). "Reaction of cytochrome oxidase with cytochrome C". J. Biol. Chem. 240 (2): 888–894. doi:10.1016/S0021-9258(17)45258-6. PMID 14275150.
  20. Brunori, M.; Gibson, Q.H. (1983). "Oxygen activation by cytochrome oxidase: A new spectral intermediate observed by flow-flash". The EMBO Journal. 2 (11): 2025–2026. doi:10.1002/j.1460-2075.1983.tb01695.x. PMC 555404. PMID 6315412.
  21. Noble, R W; Gibson, Q H (1970). "Reaction of ferrous horseradish peroxidase with hydrogen peroxide". J. Biol. Chem. 245 (9): 2409–2413. doi:10.1016/S0021-9258(18)63167-9. PMID 5442280.
  22. Alberty, Robert A. (1994). "Recommendations for nomenclature and tables in biochemical thermodynamics (IUPAC Recommendations 1994)". Pure and Applied Chemistry. 66 (8): 1641–1666. doi:10.1351/pac199466081641. S2CID 96307963.
  23. "Volume 250 Issue 24 pages 9215-9438 (J. Biol. Chem.)". 1975. Retrieved 14 April 2021.
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