Mark Wightman

Wightman received his B.A. degree with honors from Erskine College in Due West, South Carolina in 1968 and earned a Ph.D. in chemistry from the University of North Carolina at Chapel Hill in 1974, where he worked with Royce Murray. At UNC - Chapel Hill, Wightman began focusing his research on electrochemistry. Wightman was a postdoctoral researcher from 1974 to 1976 at the University of Kansas in Lawrence, Kansas under the direction of Ralph N. Adams. His work focused on electroanalytical methods and redox chemistry.[4]

Wightman worked at Indiana University Bloomington in Bloomington, Indiana from 1976 to 1989. He worked as an assistant professor from 1976 to 1982, and he was promoted to the position of associate professor in 1982 and later to a full professor in 1985. He worked as a full professor until 1989 when he took a position at the University of North Carolina at Chapel Hill.[4]

From 1989 to his retirement in 2017, Wightman was the William R. Kenan Jr. professor of chemistry at the University of North Carolina at Chapel Hill. He was appointed to the neurobiology curriculum in 1989 and was given an external faculty position at the Neuroscience Center at UNC - Chapel Hill in 2004.[4][5]

Wightman also worked as a research associate at London Hospital Medical College at the University of London in 1984. He was a visiting professor at Duke University Medical Center in Durham, NC in 1997 and at the University of Cambridge in Cambridge, England in the anatomy department in 2004. Wightman was also a visiting fellow in the Churchill College at Cambridge in 2011. He has been an advisor for over 100 doctoral students, masters students, postdoctoral associates, and visiting faculty.[4]

Wightman has also been an editor for: Biosensors & Bioelectronics, Analytical Chemistry, Journal of Electroanalytical Chemistry, Journal of Pharmacology and Experimental Therapeutics, Synapse, and Annual reviews of Analytical Chemistry.

The Wightman research group is primarily interested voltammetric sensors, particularly the ultramicroelectrode. Their small size allows for analysis and measurements at the level of a single biological cell. By coupling these electrodes to fast-scan voltammetric methods, the group has been able to monitor sub-second changes in concentrations of the neurotransmitters dopamine, norepinephrine, and serotonin in response to pharmacological and electrical stimuli.[6][7]