RAB11A

Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.[5][6]

RAB11A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAB11A, YL8, member RAS oncogene family
External IDsOMIM: 605570 MGI: 1858202 HomoloGene: 37903 GeneCards: RAB11A
Orthologs
SpeciesHumanMouse
Entrez

8766

53869

Ensembl

ENSG00000103769

ENSMUSG00000004771

UniProt

P62491

P62492

RefSeq (mRNA)

NM_004663
NM_001206836

NM_017382

RefSeq (protein)

NP_001193765
NP_004654

NP_059078

Location (UCSC)Chr 15: 65.73 – 65.89 MbChr 9: 64.62 – 64.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.[7]

Rab-11a controls intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signaling[8]

Interactions

RAB11A has been shown to interact with:

References
  1. GRCh38: Ensembl release 89: ENSG00000103769 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004771 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Drivas GT, Shih A, Coutavas EE, D'Eustachio P, Rush MG (January 1991). "Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3". Oncogene. 6 (1): 3–9. PMID 1704119.
  6. Gromov PS, Celis JE, Hansen C, Tommerup N, Gromova I, Madsen P (June 1998). "Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins". FEBS Letters. 429 (3): 359–64. doi:10.1016/S0014-5793(98)00607-3. PMID 9662449.
  7. "Entrez Gene: RAB11A RAB11A, member RAS oncogene family".
  8. Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T (October 2010). "The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes". Immunity. 33 (4): 583–96. doi:10.1016/j.immuni.2010.09.010. PMID 20933442.
  9. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
  10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  11. Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (April 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". The Journal of Biological Chemistry. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
  12. Lindsay AJ, McCaffrey MW (July 2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain". The Journal of Biological Chemistry. 277 (30): 27193–9. doi:10.1074/jbc.M200757200. PMID 11994279.
  13. Prekeris R, Davies JM, Scheller RH (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". The Journal of Biological Chemistry. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
  14. Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (December 2002). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochemical and Biophysical Research Communications. 299 (5): 770–9. doi:10.1016/s0006-291x(02)02720-1. PMID 12470645.
  15. Prekeris R, Klumperman J, Scheller RH (December 2000). "A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes". Molecular Cell. 6 (6): 1437–48. doi:10.1016/s1097-2765(00)00140-4. PMID 11163216.
  16. Ramel, Damien; Wang, Xiaobo; Laflamme, Carl; Montell, Denise J.; Emery, Gregory (March 2013). "Rab11 regulates cell–cell communication during collective cell movements". Nature Cell Biology. 15 (3): 317–324. doi:10.1038/ncb2681. ISSN 1465-7392. PMC 4006229. PMID 23376974.

Further reading
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