RAB17

RAB17
Identifiers
Aliases	RAB17, member RAS oncogene family
External IDs	OMIM: 602206 MGI: 104640 HomoloGene: 7502 GeneCards: RAB17
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	237,601,614 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	90,897,383 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of liver; ; renal medulla; ; body of pancreas; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; kidney; ; right uterine tube; ; jejunal mucosa; ; duodenum; ; right lung;
	Top expressed in
	submandibular gland; ; Paneth cell; ; jejunum; ; medullary collecting duct; ; ileum; ; duodenum; ; proximal tubule; ; parotid gland; ; crypt of lieberkuhn of small intestine; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GDP binding; GTP binding; protein binding; GTPase activity;
Cellular component	recycling endosome; endosome; cell projection; membrane; melanosome; plasma membrane; endocytic vesicle; intracellular anatomical structure; neuronal cell body; recycling endosome membrane; dendrite; basolateral plasma membrane; early endosome; apical plasma membrane; extracellular exosome;
Biological process	regulation of endocytosis; regulation of filopodium assembly; regulation of synapse assembly; filopodium assembly; regulation of dendrite development; transcytosis; establishment of melanosome localization; melanosome transport; endocytic recycling; protein transport; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; cilium assembly; transport; intracellular protein transport; Rab protein signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	64284
	19329
	ENSG00000124839
	ENSMUSG00000026304
	Q9H0T7
	P35292
	NM_022449
	NM_001159725; NM_008998
	NP_071894; NP_071894.1
	NP_001153197; NP_033024
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-17 is a protein that in humans is encoded by the RAB17 gene.[5][6]

In melanocytic cells RAB17 gene expression may be regulated by MITF.[7]

References

GRCh38: Ensembl release 89: ENSG00000124839 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026304 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem. 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.
"Entrez Gene: RAB17 RAB17, member RAS oncogene family".
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Lütcke A, Jansson S, Parton RG, et al. (1993). "Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization". J. Cell Biol. 121 (3): 553–64. doi:10.1083/jcb.121.3.553. PMC 2119572. PMID 8486736.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124839 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026304 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9624171-5] Hunziker W, Peters PJ (Jul 1998). "Rab17 localizes to recycling endosomes and regulates receptor-mediated transcytosis in epithelial cells". J Biol Chem. 273 (25): 15734–41. doi:10.1074/jbc.273.25.15734. PMID 9624171.

[entrez-6] "Entrez Gene: RAB17 RAB17, member RAS oncogene family".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

RAB17

References

Further reading