RAB25

RAB25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OIL, 3TSO
Identifiers
Aliases	RAB25, CATX-8, RAB11C, member RAS oncogene family
External IDs	OMIM: 612942 MGI: 1858203 HomoloGene: 22995 GeneCards: RAB25
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	156,070,504 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	88,455,607 bp[2]
RNA expression pattern
	Top expressed in
	skin of abdomen; ; gums; ; cavity of mouth; ; rectum; ; human penis; ; vulva; ; palpebral conjunctiva; ; body of pancreas; ; minor salivary gland; ; right uterine tube;
	Top expressed in
	lip; ; esophagus; ; epithelium of stomach; ; left colon; ; mucous cell of stomach; ; cervix; ; pyloric antrum; ; duodenum; ; skin of abdomen; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; myosin V binding; protein binding; GTPase activity;
Cellular component	pseudopodium membrane; plasma membrane; cell projection; pseudopodium; extracellular exosome; cytoplasmic vesicle; membrane; endosome; recycling endosome;
Biological process	protein transport; regulation of vesicle-mediated transport; positive regulation of epithelial cell migration; epithelial cell morphogenesis; positive regulation of cell population proliferation; pseudopodium organization; transport; intracellular protein transport; exocytosis; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	57111
	53868
	ENSG00000132698
	ENSMUSG00000008601
	P57735
	Q9WTL2
	NM_020387
	NM_016899
	NP_065120
	NP_058595
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.[5][6] It is thought to act as a promoter of tumor development.[7]

Interactions

RAB25 has been shown to interact with RAB11FIP2[8][9] and RAB11FIP5.[8][9]

References

GRCh38: Ensembl release 89: ENSG00000132698 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000008601 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
"Entrez Gene: RAB25 RAB25, member RAS oncogene family".
Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi:10.1159/000295249. PMID 22613965.
Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung". J. Biol. Chem. 268 (25): 18419–22. doi:10.1016/S0021-9258(17)46639-7. PMID 8360141.
Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Lab. Invest. 77 (5): 503–11. PMID 9389793.
Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems". Mol. Biol. Cell. 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo". Pathology. 38 (6): 561–7. doi:10.1080/00313020601024037. PMID 17393986. S2CID 85960469.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132698 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008601 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11697911-5] Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.

[entrez-6] "Entrez Gene: RAB25 RAB25, member RAS oncogene family".

[7] Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi:10.1159/000295249. PMID 22613965.

[pmid11495908-8] Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.

[pmid11481332-9] Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

RAB25

Interactions

References

Further reading