RAB38

RAB38
Identifiers
Aliases	RAB38, NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDs	OMIM: 606281 MGI: 1919683 HomoloGene: 21353 GeneCards: RAB38
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	88,175,443 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	88,140,780 bp[2]
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; vulva; ; human penis; ; skin of abdomen; ; hair follicle; ; germinal epithelium; ; cavity of mouth; ; retinal pigment epithelium; ; left adrenal gland; ; vagina;
	Top expressed in
	secondary oocyte; ; molar; ; iris; ; epidermis; ; hair follicle; ; skin of abdomen; ; cornea; ; wall of esophagus; ; nasolacrimal duct; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	AP-2 adaptor complex binding; nucleotide binding; BLOC-2 complex binding; GTP binding; GTP-dependent protein binding; protein binding; AP-3 adaptor complex binding; AP-1 adaptor complex binding; GTPase activity;
Cellular component	cytoplasm; vesicle; phagocytic vesicle membrane; Golgi apparatus; membrane; melanosome; plasma membrane; early endosome; phagocytic vesicle; endoplasmic reticulum; early endosome lumen; cytoplasmic vesicle; lysosome; mitochondrion; mitochondria-associated endoplasmic reticulum membrane; cytosol; melanosome membrane; trans-Golgi network;
Biological process	protein localization to membrane; platelet dense granule organization; organelle organization; phagosome acidification; endosome to melanosome transport; protein transport; melanosome assembly; mitochondrion organization; vesicle-mediated transport; small GTPase mediated signal transduction; post-translational protein modification; positive regulation of phosphatidylcholine biosynthetic process; intracellular protein transport; Rab protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23682
	72433
	ENSG00000123892
	ENSMUSG00000030559
	P57729
	Q8QZZ8
	NM_022337
	NM_028238
	NP_071732; NP_071732.1
	NP_082514
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.[5][6]

In melanocytic cells RAB38 gene expression may be regulated by MITF.[7]

References

GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
"Entrez Gene: RAB38 RAB38, member RAS oncogene family".
Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123892 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030559 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10910072-5] Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.

[entrez-6] "Entrez Gene: RAB38 RAB38, member RAS oncogene family".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

RAB38

References

Further reading