RABIF

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.[5][6][7]

RABIF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRABIF, MSS4, RASGFR3, RASGRF3, RAB interacting factor
External IDsOMIM: 603417 MGI: 2138605 HomoloGene: 37702 GeneCards: RABIF
Orthologs
SpeciesHumanMouse
Entrez

5877

98710

Ensembl

ENSG00000183155

ENSMUSG00000042229

UniProt

P47224

Q91X96

RefSeq (mRNA)

NM_002871

NM_145510

RefSeq (protein)

NP_002862

NP_663485

Location (UCSC)Chr 1: 202.88 – 202.89 MbChr 1: 134.42 – 134.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000183155 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042229 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM (Mar 1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer". Genomics. 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.
  6. Yu H, Schreiber SL (Aug 1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4". Biochemistry. 34 (28): 9103–10. CiteSeerX 10.1.1.540.2153. doi:10.1021/bi00028a020. PMID 7619808.
  7. "Entrez Gene: RABIF RAB interacting factor".

Further reading


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