RAE1

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.[5][6][7]

RAE1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1, Gle2
External IDsOMIM: 603343 MGI: 1913929 HomoloGene: 2676 GeneCards: RAE1
Orthologs
SpeciesHumanMouse
Entrez

8480

66679

Ensembl

ENSG00000101146

ENSMUSG00000027509

UniProt

P78406

Q8C570

RefSeq (mRNA)

NM_001015885
NM_003610

NM_175112

RefSeq (protein)

NP_001015885
NP_003601

NP_780321

Location (UCSC)Chr 20: 57.35 – 57.38 MbChr 2: 172.84 – 172.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[7]

Interactions

RAE1 has been shown to interact with NUP98.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000101146 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027509 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bharathi A, Ghosh A, Whalen WA, Yoon JH, Pu R, Dasso M, Dhar R (Dec 1997). "The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA". Gene. 198 (1–2): 251–8. doi:10.1016/S0378-1119(97)00322-3. PMID 9370289.
  6. Kraemer D, Blobel G (Sep 1997). "mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm". Proc Natl Acad Sci U S A. 94 (17): 9119–24. Bibcode:1997PNAS...94.9119K. doi:10.1073/pnas.94.17.9119. PMC 23064. PMID 9256445.
  7. "Entrez Gene: RAE1 RAE1 RNA export 1 homolog (S. pombe)".
  8. Pritchard, C E; Fornerod M; Kasper L H; van Deursen J M (Apr 1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. ISSN 0021-9525. PMC 2133102. PMID 10209021.

Further reading

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