RAP1GAP2

RAP1GAP2
Identifiers
Aliases	RAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2
External IDs	MGI: 3028623 HomoloGene: 56695 GeneCards: RAP1GAP2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	3,037,741 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	74,501,741 bp[2]
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; superior frontal gyrus; ; islet of Langerhans; ; postcentral gyrus; ; cerebellar vermis; ; entorhinal cortex; ; blood; ; pancreatic ductal cell;
	Top expressed in
	islet of Langerhans; ; primary motor cortex; ; medial vestibular nucleus; ; submandibular gland; ; prefrontal cortex; ; cingulate gyrus; ; pontine nuclei; ; epithelium of stomach; ; interventricular septum; ; visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	perinuclear region of cytoplasm; neuron projection; centrosome; plasma membrane; nuclear membrane; cytoplasm; cytosol;
Biological process	regulation of cell size; positive regulation of GTPase activity; negative regulation of neuron projection development; regulation of small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23108
	380711
	ENSG00000132359
	ENSMUSG00000038807
	Q684P5
	Q5SVL6
	NM_001100398; NM_015085; NM_001330058
	NM_001015046; NM_001364131; NM_001364132
	NP_001093868; NP_001316987; NP_055900
	NP_001015046; NP_001351060; NP_001351061; NP_001388587
	Wikidata
View/Edit Human	View/Edit Mouse

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.[5]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

References

GRCh38: Ensembl release 89: ENSG00000132359 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038807 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: RAP1 GTPase activating protein 2".

Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP (August 2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–404. doi:10.1182/blood-2008-05-155234. hdl:10197/5848. PMID 19528539. S2CID 24339637.
Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH (June 2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. doi:10.1186/1471-2261-11-29. PMC 3141757. PMID 21658281.
Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M (October 2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. doi:10.1016/j.yexcr.2004.07.011. PMID 15383317.
Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F (October 2011). "p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–58. doi:10.1093/cvr/cvr154. PMID 21632882.
Schultess J, Danielewski O, Smolenski AP (April 2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–92. doi:10.1182/blood-2004-09-3605. PMID 15632203.
Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP (January 2008). "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets" (PDF). The Journal of Biological Chemistry. 283 (4): 2297–306. doi:10.1074/jbc.M706825200. PMID 18039662. S2CID 20190382.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132359 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038807 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAP1 GTPase activating protein 2".

RAP1GAP2

References

Further reading