RASAL2

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.[5][6]

RASAL2
Identifiers
AliasesRASAL2, NGAP, RAS protein activator like 2
External IDsOMIM: 606136 MGI: 2443881 HomoloGene: 35217 GeneCards: RASAL2
Orthologs
SpeciesHumanMouse
Entrez

9462

226525

Ensembl

ENSG00000075391

ENSMUSG00000070565

UniProt

Q9UJF2

n/a

RefSeq (mRNA)

NM_004841
NM_170692

NM_177644
NM_001401202

RefSeq (protein)

NP_004832
NP_733793

n/a

Location (UCSC)Chr 1: 178.09 – 178.48 MbChr 1: 156.96 – 157.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000075391 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070565 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett. 441 (1): 127–31. doi:10.1016/S0014-5793(98)01530-0. PMID 9877179.
  6. "Entrez Gene: RASAL2 RAS protein activator like 2".

Further reading


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