RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. [5]

RASGRF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IJE
Identifiers
Aliases	RASGRF1, CDC25, CDC25L, GNRP, GRF1, GRF55, H-GRF55, PP13187, ras-GRF1, Ras protein specific guanine nucleotide releasing factor 1
External IDs	OMIM: 606600 MGI: 99694 HomoloGene: 74972 GeneCards: RASGRF1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q25.1 Start 78,959,906 bp[1] End 79,090,780 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.1|9 47.31 cM Start 89,791,961 bp[2] End 89,909,030 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 cingulate gyrus postcentral gyrus islet of Langerhans superior frontal gyrus hippocampus proper hypothalamus Brodmann area 46 substantia nigra Top expressed in pontine nuclei paraventricular nucleus of hypothalamus dorsal tegmental nucleus dorsomedial hypothalamic nucleus subiculum motor neuron arcuate nucleus suprachiasmatic nucleus lateral hypothalamus medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function guanyl-nucleotide exchange factor activity glutamate receptor binding Cellular component cytosol growth cone neuron projection plasma membrane Biological process intracellular signal transduction MAPK cascade regulation of Rho protein signal transduction positive regulation of GTPase activity signal transduction regulation of Rac protein signal transduction regulation of synaptic plasticity long-term memory regulation of Ras protein signal transduction regulation of neuronal synaptic plasticity neuron projection development regulation of NMDA receptor activity activation of GTPase activity cell population proliferation small GTPase mediated signal transduction positive regulation of Ras protein signal transduction response to endoplasmic reticulum stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5923 19417 Ensembl ENSG00000058335 ENSMUSG00000032356 UniProt Q13972 P27671 RefSeq (mRNA) NM_001145648 NM_002891 NM_153815 NM_001039655 NM_011245 NM_001357743 NM_001357744 RefSeq (protein) NP_001139120 NP_002882 NP_722522 NP_001034744 NP_035375 NP_001344672 NP_001344673 Location (UCSC) Chr 15: 78.96 – 79.09 Mb Chr 9: 89.79 – 89.91 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009].