RASGRP3

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[5][6][7]

RASGRP3
Identifiers
AliasesRASGRP3, GRP3, RAS guanyl releasing protein 3
External IDsOMIM: 609531 MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3
Orthologs
SpeciesHumanMouse
Entrez

25780

240168

Ensembl

ENSG00000152689

ENSMUSG00000071042

UniProt

Q8IV61

Q6NZH9

RefSeq (mRNA)

NM_001166493
NM_207246
NM_001360103

RefSeq (protein)

NP_001159965
NP_997129
NP_001347032

Location (UCSC)Chr 2: 33.44 – 33.56 MbChr 17: 75.74 – 75.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[7]

Interactions

RASGRP3 has been shown to interact with PRKCD.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  6. Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
  7. "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)".
  8. Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298. S2CID 5774849.

Further reading

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