RC3H1

Ring finger and CCCH-type domains 1, also known as Roquin-1, is a protein that in humans is encoded by the RC3H1 gene.[5]

RC3H1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRC3H1, RNF198, ROQUIN, ring finger and CCCH-type domains 1, FHL6, IMDSHY
External IDsOMIM: 609424 MGI: 2685397 HomoloGene: 19036 GeneCards: RC3H1
Orthologs
SpeciesHumanMouse
Entrez

149041

381305

Ensembl

ENSG00000135870

ENSMUSG00000040423

UniProt

Q5TC82

Q4VGL6

RefSeq (mRNA)

NM_001300850
NM_001300851
NM_001300852
NM_172071

NM_001024952

RefSeq (protein)

NP_001287779
NP_001287780
NP_001287781
NP_742068
NP_001287779.1

NP_001020123

Location (UCSC)Chr 1: 173.93 – 174.02 MbChr 1: 160.73 – 160.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The consensus primary sequence and secondary structure for the Roquin-1 (RC3H1) binding site (also called constitutive decay element (CDE)).

This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

References

  1. GRCh38: Ensembl release 89: ENSG00000135870 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040423 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Ring finger and CCCH-type domains 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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