RCC2

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.[5][6][7]

RCC2
Identifiers
AliasesRCC2, TD-60, regulator of chromosome condensation 2
External IDsOMIM: 609587 MGI: 1919784 HomoloGene: 10282 GeneCards: RCC2
Orthologs
SpeciesHumanMouse
Entrez

55920

108911

Ensembl

ENSG00000281540
ENSG00000179051

ENSMUSG00000040945

UniProt

Q9P258

Q8BK67

RefSeq (mRNA)

NM_018715
NM_001136204

NM_173867

RefSeq (protein)

NP_001129676
NP_061185
NP_001129676.1
NP_061185.1

NP_776292

Location (UCSC)Chr 1: 17.41 – 17.44 MbChr 4: 140.43 – 140.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.[6] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.[8][9]

References

  1. ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040945 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
  6. Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
  7. "Entrez Gene: RCC2 regulator of chromosome condensation 2".
  8. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
  9. Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.