REG3A

Regenerating islet-derived protein 3 alpha (or Regenerating islet-derived protein III-alpha) formerly known as HIP/PAP (Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-Associated Protein) and peptide 23[5] is a protein that in humans is encoded by the REG3A gene.[6][7]

REG3A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesREG3A, HIP, HIP/PAP, INGAP, PAP, PAP-H, PAP1, PBCGF, REG-III, REG3, regenerating family member 3 alpha
External IDsOMIM: 167805 MGI: 97478 HomoloGene: 130506 GeneCards: REG3A
Orthologs
SpeciesHumanMouse
Entrez

5068

18489

Ensembl

ENSG00000172016

ENSMUSG00000071356

UniProt

Q06141

P35230

RefSeq (mRNA)

NM_138938
NM_002580
NM_138937

NM_011036

RefSeq (protein)

NP_002571
NP_620354
NP_620355

NP_035166

Location (UCSC)Chr 2: 79.16 – 79.16 MbChr 6: 78.35 – 78.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. Multiple alternatively spliced transcript variants encoding the same protein have been described for this gene but the full length nature of some transcripts is not yet known.[7]

Reg3A (UniProt Q0614 1) is a bactericidal C-type lectin that is constitutively produced in the intestine that has antibacterial properties against Gram-positive bacteria. Bacterial killing is mediated by binding to surface-exposed carbohydrate moieties of bacterial peptidoglycan and executed by the formation of a hexameric pore in the membrane.[8][9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000172016 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000071356 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chakraborty C, Sharma S, Katsumata N, Murphy LJ, Schroedter IC, Robertson MC, et al. (June 1995). "Plasma clearance, tissue uptake and expression of pituitary peptide 23/pancreatitis-associated protein in the rat". The Journal of Endocrinology. 145 (3): 461–469. doi:10.1677/joe.0.1450461. PMID 7636430.
  6. Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC, Iovanna JL (January 1994). "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene". Genomics. 19 (1): 108–114. doi:10.1006/geno.1994.1019. PMID 8188210.
  7. "Entrez Gene: REG3A regenerating islet-derived 3 alpha".
  8. Murphy K, Weaver C (2017). Janeway's Immunobiology. Garland Science. p. 48. ISBN 978-0-8153-4505-3.
  9. Cash HL, Whitham CV, Behrendt CL, Hooper LV (August 2006). "Symbiotic bacteria direct expression of an intestinal bactericidal lectin". Science. 313 (5790): 1126–1130. Bibcode:2006Sci...313.1126C. doi:10.1126/science.1127119. PMC 2716667. PMID 16931762.
  10. Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, et al. (October 2011). "The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine". Science. 334 (6053): 255–258. Bibcode:2011Sci...334..255V. doi:10.1126/science.1209791. PMC 3321924. PMID 21998396.

Further reading

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