RERE

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.[5][6][7]

RERE
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRERE, ARG, ARP, ATN1L, DNB1, arginine-glutamic acid dipeptide repeats, NEDBEH
External IDsOMIM: 605226 MGI: 2683486 HomoloGene: 8101 GeneCards: RERE
Orthologs
SpeciesHumanMouse
Entrez

473

68703

Ensembl

ENSG00000142599

ENSMUSG00000039852

UniProt

Q9P2R6

Q80TZ9

RefSeq (mRNA)

NM_001042681
NM_001042682
NM_012102

NM_001085492

RefSeq (protein)

NP_001036146
NP_001036147
NP_036234

NP_001078961

Location (UCSC)Chr 1: 8.35 – 8.85 MbChr 4: 150.28 – 150.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

RERE has been shown to interact with ATN1.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000142599 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039852 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M (May 2000). "Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine". Human Molecular Genetics. 9 (9): 1433–42. doi:10.1093/hmg/9.9.1433. PMID 10814707.
  6. Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM (Mar 2000). "Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP". Genomics. 64 (2): 195–202. doi:10.1006/geno.1999.6097. PMID 10729226.
  7. "Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats".

Further reading


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