REXO2

REX2, RNA exonuclease 2 homolog (S. cerevisiae), also known as REXO2, is an enzyme which in humans is encoded by the REXO2 gene.[5][6][7]

REXO2
Identifiers
AliasesREXO2, REX2, RFN, SFN, CGI-114, RNA exonuclease 2
External IDsOMIM: 607149 MGI: 1888981 HomoloGene: 6447 GeneCards: REXO2
Orthologs
SpeciesHumanMouse
Entrez

25996

104444

Ensembl

ENSG00000076043

ENSMUSG00000032026

UniProt

Q9Y3B8

Q9D8S4

RefSeq (mRNA)

NM_015523

NM_024233
NM_001357501
NM_001357503
NM_001357505

RefSeq (protein)

NP_056338

NP_077195
NP_001344430
NP_001344432
NP_001344434

Location (UCSC)Chr 11: 114.44 – 114.45 MbChr 9: 48.38 – 48.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mono-nucleotides in a sequential manner.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000076043 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032026 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: REXO2 REX2, RNA exonuclease 2 homolog (S. cerevisiae)".
  6. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. Nguyen LH, Erzberger JP, Root J, Wilson DM (August 2000). "The human homolog of Escherichia coli Orn degrades small single-stranded RNA and DNA oligomers". J. Biol. Chem. 275 (34): 25900–6. doi:10.1074/jbc.M002672200. PMID 10851236.

Further reading


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